Role of LMP1 in immune control of EBV infection

Pai, Saparna and Khanna, Rajiv (2001) Role of LMP1 in immune control of EBV infection. Seminars in Cancer Biology, 11 6: 455-460. doi:10.1006/scbi.2001.0412

Author Pai, Saparna
Khanna, Rajiv
Title Role of LMP1 in immune control of EBV infection
Journal name Seminars in Cancer Biology   Check publisher's open access policy
ISSN 1044-579X
Publication date 2001-12
Sub-type Article (original research)
DOI 10.1006/scbi.2001.0412
Volume 11
Issue 6
Start page 455
End page 460
Total pages 6
Place of publication London, United Kingdom
Publisher Academic Press
Collection year 2001
Language eng
Subject C1
321015 Oncology and Carcinogenesis
730108 Cancer and related disorders
Abstract The Epstein-Barr virus (EBV) encoded latent membrane protein (LMP1) plays a crucial role in the long-term persistence of this virus within the cells of the immune system. Not only is this protein critical for the transformation of resting B cells by EBV, it also displays pleiotropic effects on various cellular proteins expressed in the host cell. These include up-regulation of expression of B cell activation antigens, adhesion molecules and various components of the antigen processing pathway. Here we discuss how LMP1 acts like an expression 'switch' which, depending on the stage of EBV infection, manoeuvres various pathways that either modulate the immune system towards or against its survival.
Keyword Oncology
Antigen Processing
Cytotoxic T Cells
Hla Class I
Nuclear Antigens
Cytotoxic T-lymphocytes
Latent Membrane Protein-1
Virus-associated Diseases
Vaccine Design
Polyepitope Protein
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 20 times in Thomson Reuters Web of Science Article | Citations
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Created: Tue, 14 Aug 2007, 15:34:37 EST