Analysis of the TGF beta functional pathway in epithelial ovarian carcinoma

Francis-Thickpenny, K. M., Richardson, D. ., van Ee, C. C., Love, D.R., Winship, I. M., Baguley, B. C., Chenevix-Trench, G. and Shelling, A. N. (2001) Analysis of the TGF beta functional pathway in epithelial ovarian carcinoma. British Journal of Cancer, 85 5: 687-691. doi:10.1054/bjoc.2001.1950


Author Francis-Thickpenny, K. M.
Richardson, D. .
van Ee, C. C.
Love, D.R.
Winship, I. M.
Baguley, B. C.
Chenevix-Trench, G.
Shelling, A. N.
Title Analysis of the TGF beta functional pathway in epithelial ovarian carcinoma
Journal name British Journal of Cancer   Check publisher's open access policy
ISSN 0007-0920
1532-1827
Publication date 2001
Sub-type Article (original research)
DOI 10.1054/bjoc.2001.1950
Open Access Status DOI
Volume 85
Issue 5
Start page 687
End page 691
Total pages 5
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Collection year 2001
Language eng
Abstract Epithelial ovarian carcinoma is often diagnosed at an advanced stage of disease and is the leading cause of death from gynaecological neoplasia. The genetic changes that occur during the development of this carcinoma are poorly understood. It has been proposed that IGFIIR, TGF beta1 and TGF beta RII act as a functional unit in the TGF beta growth inhibitory pathway, and that somatic loss-of-function mutations in any one of these genes could lead to disruption of the pathway and subsequent loss of cell cycle control. We have examined these 3 genes in 25 epithelial ovarian carcinomas using single-stranded conformational polymorphism analysis and DNA sequence analysis. A total of 3 somatic missense mutations were found in the TGF beta RII gene, but none in IGFRII or TGF beta1. An association was found between TGF beta RII mutations and histology, with 2 out of 3 clear cell carcinomas having TGF beta RII mutations. This data supports other evidence from mutational analysis of the PTEN and beta -catenin genes that there are distinct developmental pathways responsible for the progression of different epithelial ovarian cancer histologic subtypes. (C) 2001 Cancer Research Campaign.
Keyword Oncology
Tgf beta
Ovarian cancer
Genetic analysis
Growth-factor-beta
Molecular-genetic analysis
Clear-cell carcinoma
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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Created: Tue, 14 Aug 2007, 15:33:45 EST