Optical encoding of microbeads for gene screening: alternatives to microarrays

Battersby, BJ, Lawrie, GA and Trau, M (2001) Optical encoding of microbeads for gene screening: alternatives to microarrays. Drug Discovery Today, 6 12: S19-S26.

Author Battersby, BJ
Lawrie, GA
Trau, M
Title Optical encoding of microbeads for gene screening: alternatives to microarrays
Journal name Drug Discovery Today   Check publisher's open access policy
ISSN 1359-6446
Publication date 2001-01-01
Sub-type Critical review of research, literature review, critical commentary
Volume 6
Issue 12
Start page S19
End page S26
Total pages 8
Editor Dr Rebecca Lawrence
Place of publication Oxford
Publisher Elsevier
Collection year 2001
Language eng
Subject C1
250103 Colloid and Surface Chemistry
270800 Biotechnology
780103 Chemical sciences
Abstract Rapid access to genetic information is central to the revolution presently occurring in the pharmaceutical industry, particularly In relation to novel drug target identification and drug development. Genetic variation, gene expression, gene function and gene structure are just some of the important research areas requiring efficient methods of DNA screening. Here, we highlight state-of-the-art techniques and devices for gene screening that promise cheaper and higher-throughput yields than currently achieved with DNA microarrays. We include an overview of existing and proposed bead-based strategies designed to dramatically increase the number of probes that can be interrogated in one assay. We focus, in particular, on the issue of encoding and/or decoding (bar-coding) large bead-based libraries for HTS.
Keyword Pharmacology & Pharmacy
Oligonucleotide Hybridization
Combinatorial Chemistry
Single Microparticle
High-throughput
Quantitation
Expression
Arrays
Fluorescent
Libraries
Dna
Q-Index Code C1
Additional Notes This document is a journal review.

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: Australian Institute for Bioengineering and Nanotechnology Publications
 
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Created: Wed, 15 Aug 2007, 01:27:55 EST