Glucose induced IEG expression in the thiamin-deficient rat brain

Zimitat, C. and Nixon, P. F. (2001) Glucose induced IEG expression in the thiamin-deficient rat brain. Brain Research, 892 1: 218-227. doi:10.1016/S0006-8993(00)03297-2

Author Zimitat, C.
Nixon, P. F.
Title Glucose induced IEG expression in the thiamin-deficient rat brain
Journal name Brain Research   Check publisher's open access policy
ISSN 0006-8993
Publication date 2001
Sub-type Article (original research)
DOI 10.1016/S0006-8993(00)03297-2
Volume 892
Issue 1
Start page 218
End page 227
Total pages 10
Place of publication Amsterdam
Publisher Elsevier Science
Collection year 2001
Language eng
Subject C1
270107 Cell Neurochemistry
730104 Nervous system and disorders
1109 Neurosciences
1702 Cognitive Sciences
Abstract Glucose loading of rats made thiamin deficient by dietary deprivation of thiamin and the administration of pyrithiamin (40 mug/100 g, i.p.) precipitates an acute neuropathy, a model of Wernicke's encephalopathy in man (Zimitat and Nixon, Metab. Brain Dis. 1999;14:1-20). Immunohistochemical detection of Fos proteins was used as a marker to identify neuronal populations in the thiamin-deficient rat brain affected by glucose loading. As thiamin deficiency progressed, the extent and intensity of Fos-Like immunoreactivity (FLI) in brain structures typically affected by thiamin deficiency (the thalamus, mammillary bodies, inferior colliculus, vestibular nucleus and inferior olives) were markedly increased when compared to thiamin-replete controls. Glucose loading for 1-3 days further increased the intensity of FLI in these same regions, consistent with a dependence of Fos expression on carbohydrate metabolism as well as on thiamin deficiency. The timed acute changes that follow a bolus glucose load administered to thiamin-deficient animals may provide a sequential account of events in the pathogenesis of brain damage in this model of Wernicke's encephalopathy. (C) 2001 Elsevier Science B.V. All rights reserved.
Keyword Neurosciences
Ieg Expression
Thiamin Deficiency
Wernicke's Encephalography
Brain Damage
2 Experimental-models
Pyrithiamine-induced Lesions
Messenger-rna Expression
Fos-related Antigens
Dependent Enzymes
Extracellular Glutamate
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collection: Queensland Brain Institute Publications
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Citation counts: TR Web of Science Citation Count  Cited 11 times in Thomson Reuters Web of Science Article | Citations
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Created: Tue, 14 Aug 2007, 15:17:28 EST