Can increasing the viscosity of formulations be used to reduce the human skin penetration of the sunscreen oxybenzone?

Cross, Sheree E., Jiang, Ruoying, Benson, Heather A. E. and Roberts, Michael S. (2001) Can increasing the viscosity of formulations be used to reduce the human skin penetration of the sunscreen oxybenzone?. The Journal of Investigative Dermatology, 117 1: 147-150.


Author Cross, Sheree E.
Jiang, Ruoying
Benson, Heather A. E.
Roberts, Michael S.
Title Can increasing the viscosity of formulations be used to reduce the human skin penetration of the sunscreen oxybenzone?
Journal name The Journal of Investigative Dermatology   Check publisher's open access policy
Publication date 2001
Sub-type Article
DOI 10.1046/j.1523-1747.2001.01398.x
Volume number 117
Issue number 1
ISSN 0022-202X
Start page 147
End page 150
Total pages 4
Place of publication Malden, USA
Publisher Blackwell Science
Collection year 2001
Language eng
Subject C1
320501 Pharmaceutical Sciences and Pharmacy
730117 Skin and related disorders
Abstract The effect of adding thickening agents on the penetration of a sunscreen benzophenone-3 through epidermal and a high-density polyethylene membrane was studied using both very thick (infinite dose) and thin tin use) applications. Contradictory results were obtained. Thickening agents retard skin penetration, in a manner consistent with a diffusional resistance in the formulation, when applied as an infinite dose. In contrast, when applied as in thin (in use) doses, thickening agents promote penetration, most likely through greater stratum corneum diffusivity arising from an enhanced hydration by the thicker formulations. The two key implications from this work are (i) a recognition of the danger in the potential extrapolation of infinite dosing to in use situations, and (ii) to recognize that thicker formulations may sometimes enhance the penetration of other topical agents when applied in use.
Keyword Dermatology
Epidermis
Finite Dosing
Hydration
Infinite Dosing
Products
Q-Index Code C1

Document type: Journal Article
Sub-type: Article
Collections: School of Medicine Publications
School of Pharmacy Publications
 
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Created: Tue, 14 Aug 2007, 15:13:37 EST