An Australian twin study of the genetic basis of preeclampsia and eclampsia

Treloar, Susan A., Cooper, Desmond W., Brennecke, Shaun P., Grehan, Madonna M. and Martin, Nicholas G. (2001) An Australian twin study of the genetic basis of preeclampsia and eclampsia. American Journal of Obstetrics And Gynecology, 184 3: 374-381. doi:10.1067/mob.2001.109400


Author Treloar, Susan A.
Cooper, Desmond W.
Brennecke, Shaun P.
Grehan, Madonna M.
Martin, Nicholas G.
Title An Australian twin study of the genetic basis of preeclampsia and eclampsia
Journal name American Journal of Obstetrics And Gynecology   Check publisher's open access policy
ISSN 0002-9378
Publication date 2001
Sub-type Article (original research)
DOI 10.1067/mob.2001.109400
Volume 184
Issue 3
Start page 374
End page 381
Total pages 8
Place of publication St. Louis, USA
Publisher Mosby Inc
Collection year 2001
Language eng
Subject C1
321011 Medical Genetics
730107 Inherited diseases (incl. gene therapy)
Abstract OBJECTIVE: We investigated maternal versus fetal genetic causes of preeclampsia and eclampsia by assessing concordance between monozygotic and dizygotic female co-twins, between female partners of male monozygotic and dizygotic twin pairs, and between female twins and partners of their male co-twins in dizygotic opposite-sex pairs. STUDY DESIGN: Two large birth cohorts of volunteer Australian female twin pairs (N = 1504 pairs and N = 858 pairs) were screened and interviewed, and available medical and hospital records were obtained and reviewed where indicated, with diagnoses assigned according to predetermined criteria. RESULTS: With strict diagnostic criteria used for preeclampsia and eclampsia, no concordant female twin pairs were found. Collapsing diagnoses of definite, probable, or possible preeclampsia or eclampsia resulted in very low genetic recurrence risk estimates. CONCLUSION: Results from these two cohorts of female twin pairs do not support clear, solely maternal genetic influences on preeclampsia and eclampsia. Numbers of parous female partners of male twins were too low for conclusions to be drawn regarding paternal transmission.
Keyword Obstetrics & Gynecology
Genetic
Preeclampsia
Twin Study
Complex Traits
Hypertension
Pregnancy
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: School of Population Health Publications
School of Medicine Publications
School of Psychology Publications
 
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