Compartmentalization of Ras proteins

Prior, I. A. and Hancock, J. F. (2001) Compartmentalization of Ras proteins. Journal of Cell Science, 114 9: 1603-1608.

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Author Prior, I. A.
Hancock, J. F.
Title Compartmentalization of Ras proteins
Journal name Journal of Cell Science   Check publisher's open access policy
ISSN 0021-9533
Publication date 2001
Sub-type Article (original research)
Open Access Status File (Publisher version)
Volume 114
Issue 9
Start page 1603
End page 1608
Total pages 6
Place of publication Cambridge, UK
Publisher Cambridge University Press
Collection year 2001
Language eng
Subject C1
321015 Oncology and Carcinogenesis
730108 Cancer and related disorders
Abstract The Ras GTPases operate as molecular switches that link extracellular stimuli with a diverse range of biological outcomes. Although many studies have concentrated on the protein-protein interactions within the complex signaling cascades regulated by Ras, it is becoming clear that the spatial orientation of different Ras isoforms within the plasma membrane is also critical for their function. H-Ras, N-Ras and K-Ras use different membrane anchors to attach to the plasma membrane. Recently it has been shown that these anchors also act as trafficking signals that direct palmitoylated H-Ras and N-Ras through the exocytic pathway to the cell surface but divert polybasic K-Ras around the Golgi to the plasma membrane via an as yet-unidentified-route. Once at the plasma membrane, H-Ras and :K-Ras operate in different microdomains. K-Ras is localized predominantly to the disordered plasma membrane, whereas H-Ras exists in a GTP-regulated equilibrium between disordered plasma membrane and cholesterol-rich lipid rafts. These observations provide a likely explanation for the increasing number of biological differences being identified between the otherwise highly homologous Ras isoforms and raise interesting questions about the role membrane microlocalization plays in determining the interactions of Ras with its effecters and exchange factors.
Keyword Cell Biology
Lipid Rafts
Plasma Membrane
Palmitoyl Acyltransferase
Increasing Complexity
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
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Created: Tue, 14 Aug 2007, 15:10:05 EST