Determinants of hepato- and spleno-megaly in Hunan, China: cross-sectional survey data from areas endemic for schistosomiasis

Yu, D. B., Ross, A. G. P., Williams, G. M., Li, Y. S. and McManus, D. P. (2001) Determinants of hepato- and spleno-megaly in Hunan, China: cross-sectional survey data from areas endemic for schistosomiasis. Annals of Tropical Medicine And Parasitology, 95 7: 707-713. doi:10.1080/00034980120103261


Author Yu, D. B.
Ross, A. G. P.
Williams, G. M.
Li, Y. S.
McManus, D. P.
Title Determinants of hepato- and spleno-megaly in Hunan, China: cross-sectional survey data from areas endemic for schistosomiasis
Journal name Annals of Tropical Medicine And Parasitology   Check publisher's open access policy
ISSN 0003-4983
1364-8594
Publication date 2001
Sub-type Article (original research)
DOI 10.1080/00034980120103261
Volume 95
Issue 7
Start page 707
End page 713
Total pages 7
Editor D.H. Molyneaux
Place of publication London
Publisher Maney
Collection year 2001
Language eng
Subject C1
320405 Medical Parasitology
730118 Organs, diseases and abnormal conditions not elsewhere classified
1117 Public Health and Health Services
Abstract In order to understand the determinants of schistosome-related hepato- and spleno-megaly better, 14 002 subjects aged 3-60 years (59% male; mean age =32 years) were randomly selected from 43 villages, all in Hunan province, China, where schistosomiasis caused by Schistosoma japonicum is endemic. The abdomen of each subject was examined along the mid-sternal (MSL) and mid-clavicular lines, for evidence of current hepato- and/or spleno-megaly, and a questionnaire was used to collect information on the medical history of each individual. Current infections with S. japonicum were detected by stool examination. Almost all (99.8%) of the subjects were ethnically Han by descent and most (77%) were engaged in farming. Although schistosomiasis appeared common (42% of the subjects claiming to have had the disease), only 45% of the subjects said they had received anti-schistosomiasis drugs. Overall, 1982 (14%) of the subjects had S. japonicum infections (as revealed by miracidium-hatching tests and/or Katon Katz smears) when examined and 22% had palpable hepatomegaly (i.e. enlargement of at least 3 cm along the MSL), although only 2.5% had any form of detectable splenomegaly (i.e. a Hackett's grade of at least 1). Multiple logistic regression revealed that male subjects, fishermen, farmers, subjects aged greater than or equal to 25 years, subjects with a history of schistosomiasis, and subjects who had had bloody stools in the previous 2 weeks were all at relatively high risk of hepato- and/or spleno-megaly. In areas moderately endemic for Schistosoma japonicum, occupational exposure and disease history appear to be good predictors of current disease status among older residents. These results reconfirm those reported earlier in the same region.
Keyword Public, Environmental & Occupational Health
Parasitology
Tropical Medicine
Dongting Lake Region
Japonicum Infection
3 Villages
Morbidity
Fibrosis
Impact
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Public Health Publications
 
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Created: Tue, 14 Aug 2007, 15:05:37 EST