Temporal relationship between the auditory brainstem response and focal responses of auditory nerve root and cochlear nucleus during development in the tammar wallaby (Macropus eugenii)

Liu, G. B., Hill, K. G. and Mark, R. F. (2001) Temporal relationship between the auditory brainstem response and focal responses of auditory nerve root and cochlear nucleus during development in the tammar wallaby (Macropus eugenii). Audiology and Neuro-otology, 6 3: 140-153. doi:10.1159/000046821


Author Liu, G. B.
Hill, K. G.
Mark, R. F.
Title Temporal relationship between the auditory brainstem response and focal responses of auditory nerve root and cochlear nucleus during development in the tammar wallaby (Macropus eugenii)
Journal name Audiology and Neuro-otology   Check publisher's open access policy
ISSN 1420-3030
Publication date 2001
Sub-type Article (original research)
DOI 10.1159/000046821
Volume 6
Issue 3
Start page 140
End page 153
Total pages 14
Editor Manfried Hoke
Place of publication Basel
Publisher S.Karger AG
Collection year 2001
Language eng
Subject C1
270502 Neurobiology
730111 Hearing, vision, speech and their disorders
Abstract Thirty-two pouch-young tammar wallabies were used to discover the generators of the auditory brainstem response (ABR) during development by the use of simultaneous ABR and focal brainstem recordings. A click response from the auditory nerve root (ANR) in the wallaby was recorded from postnatal day (PND) 101, when no central auditory station was functional, and coincided with the ABR, a simple positive wave. The response of the cochlear nucleus (CN) was detected from PND 110, when the ABR had developed 1 positive and 1 negative peak. The dominant component of the focal ANR response, the N-1 wave, coincided with the first half of the ABR P wave, and that of the focal CN response, the N-1 wave, coincided with the later two thirds. In older animals, the ANR response coincided with the ABR's N-1, wave, while the CN response coincided with the ABR's P-2, N-2 and P-3 waves, with its contribution to the ABR P-2 dominant. The protracted development of the marsupial auditory system which facilitated these correlations makes the tammar wallaby a particularly suitable model. Copyright (C) 2001 S. Karger AG, Basel.
Keyword Neurosciences
Otorhinolaryngology
Auditory Development
Wallaby
Macropus Eugenii
Auditory Brainstem Response
Stem Evoked-potentials
Source Density Analysis
Induced Neuronal Loss
Inferior Colliculus
Trapezoid Body
Guinea-pigs
Cat
Generators
Lesions
Origin
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Biological Sciences Publications
 
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Created: Tue, 14 Aug 2007, 15:05:07 EST