Timely topic: Premalignant lesions associated with adenocarcinoma of the upper gastrointestinal tract

Clouston, Andrew D. (2001) Timely topic: Premalignant lesions associated with adenocarcinoma of the upper gastrointestinal tract. Pathology, 33 3: 271-277. doi:10.1080/00313020120070830


Author Clouston, Andrew D.
Title Timely topic: Premalignant lesions associated with adenocarcinoma of the upper gastrointestinal tract
Journal name Pathology   Check publisher's open access policy
ISSN 0031-3025
1465-3931
Publication date 2001
Sub-type Article (original research)
DOI 10.1080/00313020120070830
Volume 33
Issue 3
Start page 271
End page 277
Total pages 7
Place of publication Abingdon, England
Publisher Informa Healthcare
Collection year 2001
Language eng
Subject C1
321006 Gastroenterology and Hepatology
730113 Digestive system and disorders
Abstract The changing incidence of adenocarcinomas, particularly in the oesophagus and gastric cardia, has led to the rapid expansion of screening programmes aimed at detecting the precursor lesion of dysplasia before adenocarcinoma develops. The pathologist now has an important role in first diagnosing patients at risk for developing dysplasia, and then correctly classifying dysplasia when it occurs. Barrett's oesophagus has had different diagnostic criteria in previous years but is currently diagnosed by the presence of intestinal metaplasia of any length in the true oesophagus. Intestinal metaplasia confined only to the gastro-oesophageal junction or cardia is of uncertain significance but is probably common, with less risk of progressing to dysplasia or malignancy. In the stomach, patients with autoimmune atrophic gastritis and Helicobacter-associated multifocal atrophic gastritis have an increased risk of adenocarcinoma, but screening protocols are not well-developed compared with those used for Barrett's oesophagus. Dysplasia of glandular epithelium can be classified using well-described criteria. Low grade dysplasia is the most common type and regresses or remains stable in the majority of patients. High grade dysplasia is more ominous clinically, with a propensity to coexist with or progress to adenocarcinoma.
Keyword Pathology
Barrett's Oesophagus
Barrett's Esophagus
Intestinal Metaplasia
Dysplasia
Adenocarcinoma
Gastroesophageal Reflux Disease
Segment Barretts-esophagus
Helicobacter-pylori
Gastric-cancer
Esophagogastric Junction
Columnar Cells
Follow-up
Prevalence
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Biomedical Sciences Publications
 
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Created: Tue, 14 Aug 2007, 14:59:07 EST