Molecular and cellular biology of pre-malignancy in the gastrointestinal tract

Jass, Jeremy R. and Talbot, Ian C. (2001) Molecular and cellular biology of pre-malignancy in the gastrointestinal tract. Best Practice & Research In Clinical Gastroenterology, 15 2: 175-189. doi:10.1053/bega.2000.0168

Author Jass, Jeremy R.
Talbot, Ian C.
Title Molecular and cellular biology of pre-malignancy in the gastrointestinal tract
Journal name Best Practice & Research In Clinical Gastroenterology   Check publisher's open access policy
ISSN 1521-6918
Publication date 2001-04
Sub-type Article (original research)
DOI 10.1053/bega.2000.0168
Volume 15
Issue 2
Start page 175
End page 189
Total pages 15
Place of publication London ; Sydney
Publisher Bailliere Tindall
Collection year 2001
Language eng
Subject C1
321006 Gastroenterology and Hepatology
730108 Cancer and related disorders
Abstract Important pathogenic alterations within established cancers are acquired during the premalignant stage. These genetic alterations can be grouped into specific neoplastic pathways that differ within and between anatomical sites. By understanding the mechanisms that determine the initiation and progression of each pathway, it will be possible to develop novel approaches to the diagnosis, prevention and treatment of cancer. This chapter outlines the principles underlying the molecular characterization of pre-malignant lesions, taking colorectal neoplasia as the main model.
Keyword Gastroenterology & Hepatology
Genetic Instability
Tumour Suppressor Genes
Nonpolyposis Colorectal-cancer
Adenoma-carcinoma Sequence
Island Methylator Phenotype
Aberrant Crypt Foci
Ki-ras Mutations
Microsatellite Instability
P53 Immunohistochemistry
Neoplastic Progression
Hyperplastic Polyps
Genetic Alterations
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 13 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 12 times in Scopus Article | Citations
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Created: Tue, 14 Aug 2007, 14:57:08 EST