Hyperplastic polyps of the colorectum - Innocent or guilty?

Jass, J. R. (2001) Hyperplastic polyps of the colorectum - Innocent or guilty?. Diseases of The Colon & Rectum, 44 2: 163-166. doi:10.1007/BF02234287

Author Jass, J. R.
Title Hyperplastic polyps of the colorectum - Innocent or guilty?
Journal name Diseases of The Colon & Rectum   Check publisher's open access policy
ISSN 0012-3706
Publication date 2001
Sub-type Article (original research)
DOI 10.1007/BF02234287
Volume 44
Issue 2
Start page 163
End page 166
Total pages 4
Place of publication Philadelphia
Publisher Lippincott Williams & Wilkins
Collection year 2001
Language eng
Subject C1
321006 Gastroenterology and Hepatology
730108 Cancer and related disorders
1103 Clinical Sciences
1112 Oncology and Carcinogenesis
Abstract Hyperplastic polyps have traditionally been regarded as nonneoplastic polyps lacking malignant potential. The demonstration of genetic alterations within these lesions indicates an underlying neoplastic cause. There is evidence that hyperplastic polyps are heterogeneous. Most are innocuous, but subsets may have malignant potential. Risk factors for neoplastic progression include multiple, large, and proximally located polyps. Aberrant methylation resulting in the silencing of cancer genes may be an important underlying mechanism, particularly in pathways progressing to tumors with DNA microsatellite instability. Lesions intermediate between hyperplastic polyp and cancer include admired polyps and serrated adenomas. Currently, pathologists have different thresholds for diagnosing serrated adenomas, including the distinction from large hyperplastic polyps. Reasons for over looking this pathway in the past may include rapid tumor progression and the fact that proximally located hyperplastic polyps may be flat and not especially numerous. Management of the serrated pathway of colorectal neoplasia may require novel approaches to screening, early detection, and prevention.
Keyword Gastroenterology & Hepatology
Serrated Adenomas
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
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Created: Tue, 14 Aug 2007, 14:57:02 EST