Growth hormone induces bone morphogenetic proteins and bone-related proteins in the developing rat periodontium

Li, Huika, Bartold, P. Mark, Young, William G., Xiao, Yin and Waters, Michael J. (2001) Growth hormone induces bone morphogenetic proteins and bone-related proteins in the developing rat periodontium. Journal of Bone And Mineral Research, 16 6: 1068-1076. doi:10.1359/jbmr.2001.16.6.1068


Author Li, Huika
Bartold, P. Mark
Young, William G.
Xiao, Yin
Waters, Michael J.
Title Growth hormone induces bone morphogenetic proteins and bone-related proteins in the developing rat periodontium
Journal name Journal of Bone And Mineral Research   Check publisher's open access policy
ISSN 0884-0431
1523-4681
Publication date 2001-06
Sub-type Article (original research)
DOI 10.1359/jbmr.2001.16.6.1068
Volume 16
Issue 6
Start page 1068
End page 1076
Total pages 9
Editor M.K. Drezner
Place of publication Washington, D. C., U.S.A.
Publisher American Society for Bone and Mineral Research
Collection year 2001
Language eng
Subject C1
320899 Dentistry not elsewhere classified
730112 Oro-dental and disorders
270602 Animal Physiology - Cell
630104 Dairy cattle
Abstract The hypothesis that growth hormone (GH) up-regulates the expression of enzymes, matrix proteins, and differentiation markers involved in mineralization of tooth and bone matrices was tested by the treatment of Lewis dwarf rats with GH over 5 days, The molar teeth and associated alveolar bone were processed for immunohistochemical demonstration of bone morphogenetic proteins 2 and 4 (BMP-2 and -4), bone morphogenetic protein type IA receptor (BMPR-IA), bone alkaline phosphatase (ALP), osteocalcin (OC), osteopontin (OPN), bone sialoprotein (BSP), and E11 protein (E11), The cementoblasts, osteoblasts, and periodontal ligament (PDL) cells responded to GH by expressing BMP-2 and -4, BMPR-IA, ALP, OC, and OPN and increasing the numbers of these cells. No changes were found in patterns of expression of the late differentiation markers BSP and E11 in response to GH, Thus, GH evokes expression of bone markers of early differentiation in cementoblasts, PDL cells, and osteoblasts of the periodontium. We propose that the induction of BMP-2 and -4 and their receptor by GH compliments the role of GH-induced insulin-like growth factor 1 (IGF-1) in promoting bone and tooth root formation.
Keyword Endocrinology & Metabolism
Growth Hormone
Bone Morphogenetic Protein
Bone Formation Marker
Periodontium
Cementum
Expression Patterns
Cementum Formation
Root-formation
Alveolar Bone
I Receptors
Sialoprotein
Differentiation
Osteopontin
Tissues
Molar
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: School of Dentistry Publications
School of Biomedical Sciences Publications
 
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Created: Tue, 14 Aug 2007, 14:52:21 EST