Novel gene containing multiple epidermal growth factor-like motifs transiently expressed in the papillae of the ascidian tadpole larvae

Arnold, JM, Eri, R, Degnan, BM and Lavin, MF (1997) Novel gene containing multiple epidermal growth factor-like motifs transiently expressed in the papillae of the ascidian tadpole larvae. Developmental Dynamics, 210 3: 264-273. doi:10.1002/(SICI)1097-0177(199711)210:3<264::AID-AJA7>3.0.CO;2-E


Author Arnold, JM
Eri, R
Degnan, BM
Lavin, MF
Title Novel gene containing multiple epidermal growth factor-like motifs transiently expressed in the papillae of the ascidian tadpole larvae
Journal name Developmental Dynamics   Check publisher's open access policy
ISSN 1058-8388
Publication date 1997-01-01
Sub-type Article (original research)
DOI 10.1002/(SICI)1097-0177(199711)210:3<264::AID-AJA7>3.0.CO;2-E
Volume 210
Issue 3
Start page 264
End page 273
Total pages 10
Language eng
Abstract We have investigated molecular mechanisms of the embryonic development of an ascidian, a primitive chordate which shares features of both invertebrates and vertebrates, with a view to identifying genes involved in development and metamorphosis, We isolated 12 partial cDNA sequences which were expressed in a stage-specific manner using differential display, We report here the isolation of a full-length cDNA sequence for one of these genes which was specifically expressed during the tailbud and larval stages of ascidian development, This cDNA, 1213 bp in length, is predicted to encode a protein of 337 amino acids containing four epidermal growth factor (EGF)-like repeats and three novel cysteine-rich repeats, Characterization of its spatial expression pattern by in situ hybridisation in late tailbud and larval embryos demonstrated strong expression localised throughout the papillae and anteriormost trunk and weaker expression in the epidermis of the remainder of the embryo, As recent evidence indicates that the signal for metamorphosis originates in the anterior trunk region, these results suggest that this gene may have a role in signalling the initiation of metamorphosis. (C) 1997 Wiley-Liss, Inc.
Keyword Anatomy & Morphology
Developmental Biology
Ascidian
Egf-like Domain
Gene Expression
In Situ Hybridization
Metamorphosis
Factor-like Domain
Extracellular-matrix
Calcium-binding
Nervous-system
Sequence
Protein
Cdna
Mouse
Organization
Precursor
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Biological Sciences Publications
 
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Created: Tue, 14 Aug 2007, 03:01:56 EST