A polydnavirus-encoded protein of an endoparasitoid wasp is an immune suppressor

Asgari, S, Schmidt, O and Theopold, U (1997) A polydnavirus-encoded protein of an endoparasitoid wasp is an immune suppressor. Journal of General Virology, 78 : 3061-3070.

Author Asgari, S
Schmidt, O
Theopold, U
Title A polydnavirus-encoded protein of an endoparasitoid wasp is an immune suppressor
Journal name Journal of General Virology   Check publisher's open access policy
ISSN 0022-1317
Publication date 1997
Sub-type Article (original research)
Volume 78
Start page 3061
End page 3070
Total pages 10
Language eng
Abstract The molecular mechanism by which polydnaviruses of endoparasitoid wasps disrupt cell-mediated encapsulation reactions of host insects is largely unknown. Here we show that a polydnavirus-encoded protein, produced from baculovirus and plasmid expression vectors, prevents cell surface exposure of lectin-binding sites and microparticle formation during immune stimulation of haemocytes. The inactivation of immune-related cellular processes by this protein was analysed using a specific lectin and annexin V and shown to be virtually identical to polydnavirus-mediated effects on haemocytes. Cytochalasin D application has similar effects on haemocytes, suggesting that the immune suppression by the polydnavirus protein is caused by the destabilization of actin filaments. Since the exposure of cell surface glycoproteins and the formation of microparticles are part of an immune response to foreign objects or microorganisms and a prerequisite for cell-mediated encapsulation of microorganisms and parasites, the virus-encoded protein may become an important tool for the inactivation of cellular immune reactions in insects and an essential component in understanding immune suppression in parasitized host insects.
Keyword Biotechnology & Applied Microbiology
Virology
Cell-surface Changes
Pseudoplusia-includens
Microplitis-demolitor
Heliothis-virescens
Human Neutrophils
Pieris-rapae
Host
Drosophila
Insect
Venom
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Biological Sciences Publications
 
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Created: Mon, 13 Aug 2007, 17:01:31 EST