A risk index for early node-negative breast cancer

Boyages, J., Taylor, R., Chua, B., Ung, O., Bilous, M., Salisbury, E. and Wilcken, N. (2006) A risk index for early node-negative breast cancer. British Journal of Surgery, 93 5: 564-571. doi:10.1002/bjs.5207

Author Boyages, J.
Taylor, R.
Chua, B.
Ung, O.
Bilous, M.
Salisbury, E.
Wilcken, N.
Title A risk index for early node-negative breast cancer
Journal name British Journal of Surgery   Check publisher's open access policy
ISSN 0007-1323
Publication date 2006-05
Sub-type Article (original research)
DOI 10.1002/bjs.5207
Volume 93
Issue 5
Start page 564
End page 571
Total pages 8
Place of publication West Sussex, United Kingdom
Publisher John Wiley & Sons
Language eng
Subject 11 Medical and Health Sciences
1117 Public Health and Health Services
Formatted abstract
This study compared the application of the St Gallen 2001 classification with a risk index developed at the New South Wales Breast Cancer Institute (BCI Index) for women with node-negative breast cancer treated without adjuvant systemic therapy.

The BCI risk categories were constructed by identifying combinations of prognostic indicators that produced homogeneous low-, intermediate- and high-risk groups using the same variables as in the St Gallen classification.


The BCI low-risk category consisted of women aged 3 5 years or more with a grade 1 oestrogen receptor (ER)-positive tumour 20 turn or less in diameter, or with a grade 2 ER-positive tumour of 15 turn or less. This category constituted 40.1 per cent of patients, with a 10-year distant relapse-free survival (DRFS) rate of 97.2 per cent. The BCI intermediate- risk category included women aged 35 years or more with a grade 2 ER-positive turnout of diameter 16-20 mm, or a grade 1 or 2 ER-negative tumour measuring 15 mm or less, and comprised 12.1 percent of the women, with a 10-year DRFS rate of 88 per cent. The high-risk category comprised 47.7 per cent of women, with a 10-year DRFS rate of 68.4 per cent.


If confirmed in other data sets, the BCI Index may be used to identify women at low risk of distant relapse (2.8 per cent at 10 years) who are unlikely to benefit from adjuvant systemic therapy, and women at intermediate risk of distant relapse (12 per cent at 10 years) in whom the benefit of adjuvant systemic therapy is small.
Keyword Surgery
Median Follow-up
Stage-i T1n0m0
Q-Index Code C1
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Public Health Publications
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Created: Mon, 13 Aug 2007, 16:14:32 EST