Executive "brake failure" following deactivation of human frontal lobe

Chambers, C. D., Bellgrove, M. A., Stokes, M. G., Henderson, T. R., Garavan, H., Robertson, I. H., Morris, A. P. and Mattingley, J. B. (2006) Executive "brake failure" following deactivation of human frontal lobe. Journal of Cognitive Neuroscience, 18 3: 444-455. doi:10.1162/089892906775990606

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Author Chambers, C. D.
Bellgrove, M. A.
Stokes, M. G.
Henderson, T. R.
Garavan, H.
Robertson, I. H.
Morris, A. P.
Mattingley, J. B.
Title Executive "brake failure" following deactivation of human frontal lobe
Journal name Journal of Cognitive Neuroscience   Check publisher's open access policy
ISSN 0898-929X
1530-8898
Publication date 2006-03-01
Sub-type Article (original research)
DOI 10.1162/089892906775990606
Open Access Status File (Publisher version)
Volume 18
Issue 3
Start page 444
End page 455
Total pages 12
Place of publication Cambridge, MA, United States
Publisher M I T Press
Language eng
Abstract In the course of daily living, humans frequently encounter situations in which a motor activity, once initiated, becomes unnecessary or inappropriate. Under such circumstances, the ability to inhibit motor responses can be of vital importance. Although the nature of response inhibition has been studied in psychology for several decades, its neural basis remains unclear. Using transcranial magnetic stimulation, we found that temporary deactivation of the pars opercularis in the right inferior frontal gyrus selectively impairs the ability to stop an initiated action. Critically, deactivation of the same region did not affect the ability to execute responses, nor did it influence physiological arousal. These findings confirm and extend recent reports that the inferior frontal gyrus is vital for mediating response inhibition.
Keyword Neurosciences
Psychology, Experimental
Transcranial Magnetic Stimulation
Attention-deficit/hyperactivity Disorder
Cognitive-energetic Model
Stop-signal Inhibition
Event-related Fmri
Prefrontal Cortex
Response-inhibition
Spatial Attention
Functional Mri
Task
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
Queensland Brain Institute Publications
 
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Created: Tue, 14 Aug 2007, 02:04:12 EST