Cholestanol: A serum marker to guide LDL cholesterol-lowering therapy

Hoenig, Michel R., Rolfe, Barbara E. and Campbell, Julie H. (2006) Cholestanol: A serum marker to guide LDL cholesterol-lowering therapy. Atherosclerosis, 184 2: 247-254. doi:10.1016/j.atherosclerosis.2005.09.007

Author Hoenig, Michel R.
Rolfe, Barbara E.
Campbell, Julie H.
Title Cholestanol: A serum marker to guide LDL cholesterol-lowering therapy
Journal name Atherosclerosis   Check publisher's open access policy
ISSN 0021-9150
Publication date 2006-02
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.atherosclerosis.2005.09.007
Volume 184
Issue 2
Start page 247
End page 254
Total pages 8
Place of publication Clare
Publisher Elsevier Ireland Ltd
Collection year 2005
Language eng
Subject 321003 Cardiology (incl. Cardiovascular Diseases)
320000 Medical and Health Sciences
730106 Cardiovascular system and diseases
Abstract Statins have been the mainstay of lipid-lowering therapy since their introduction. However, as lower LDL cholesterol targets are sought, adjunct therapies are becoming increasingly important. Few patients reach new targets with statin monotherapy. We propose that the cholestanol: cholesterol ratio can be used to guide lipid-lowering therapy and result in greater numbers of patients reaching target LDL cholesterol. By determining whether a patient is mainly a synthesizer or absorber of cholesterol, customized regimens can be used and are expected to improve patient outcomes and minimize costs of treatment. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
Keyword Peripheral Vascular Disease
Bile Acid Binding Resins
Ncep Atpiii
Apolipoprotein-e Polymorphism
Coa Reductase Inhibitors
Plant Sterol Levels
Familial Hypercholesterolemia
Noncholesterol Sterols
Absorption Efficiency
Q-Index Code C1

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Created: Mon, 13 Aug 2007, 15:58:52 EST