The mechanism of inflammation in RelB deficient mice

Pai, S., O'Sullivan, B. J., MacDonald, K. P., Duggan, E., Gerondakis, S., Hill, G. and Thomas, R. (2005). The mechanism of inflammation in RelB deficient mice. In: Tissue Antigens: 'Genetics and The Immune Response' Abstracts of the 35th Annual Scientific Meeting of the Australasian Society for Immunology and 14th International HLA and Immunogenetics Workshop. 35th Annual Scentific Meeting of the Australasian-Society-for-Immunology/14th International HLA and Immunogenetics Workshops, Melbourne, Australia, (507-507). 29 November - 2 December 2005.


Author Pai, S.
O'Sullivan, B. J.
MacDonald, K. P.
Duggan, E.
Gerondakis, S.
Hill, G.
Thomas, R.
Title of paper The mechanism of inflammation in RelB deficient mice
Conference name 35th Annual Scentific Meeting of the Australasian-Society-for-Immunology/14th International HLA and Immunogenetics Workshops
Conference location Melbourne, Australia
Conference dates 29 November - 2 December 2005
Proceedings title Tissue Antigens: 'Genetics and The Immune Response' Abstracts of the 35th Annual Scientific Meeting of the Australasian Society for Immunology and 14th International HLA and Immunogenetics Workshop   Check publisher's open access policy
Journal name Tissue Antigens   Check publisher's open access policy
Publisher Australasian Society of Immunology
Publication Year 2005
Sub-type Published abstract
ISSN 0001-2815
1399-0039
Volume 66
Issue 5
Start page 507
End page 507
Total pages 1
Language eng
Abstract/Summary RelB, NIK and TRAF6-deficient mice die prematurely with multi-organ inflammatory disease and apparent excessive myelopoiesis. While thymic development of CD4+CD25+ regulatory T cells (Treg) is reduced in TRAF6 deficient mice, the impact of this on inflammation is not known. Here we show that while RelB deficient thymic stroma is unable to sustain the development of Treg, surprisingly, FoxP3hi Treg are increased in the periphery. Peripheral expansion of Treg is driven by GITRligand, expressed by immature monocytes maintained by RelBdeficient stroma. RelB-deficient DC fail to activate Treg suppressor function. The data reveal the dual roles of RelB in both hemopoietic and stromal cells to maintain tolerance and contain inflammation through Treg and DC.
Subjects 1107 Immunology
Keyword Cell Biology
Immunology
Pathology
Q-Index Code EX
Q-Index Status Provisional Code
Institutional Status Unknown

 
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Created: Mon, 13 Aug 2007, 15:44:18 EST