Association between dopamine transporter (DATI) genotype, left-sided inattention, and an enhanced response to methylphenidate in attention-deficit hyperactivity disorder

Bellgrove, M. A., Hawi, Z., Kirley, A., Fitzgerald, M., Gill, M. and Robertson, I. H. (2005) Association between dopamine transporter (DATI) genotype, left-sided inattention, and an enhanced response to methylphenidate in attention-deficit hyperactivity disorder. Neuropsychopharmacology, 30 12: 2290-2297. doi:10.1038/sj.npp.1300839


Author Bellgrove, M. A.
Hawi, Z.
Kirley, A.
Fitzgerald, M.
Gill, M.
Robertson, I. H.
Title Association between dopamine transporter (DATI) genotype, left-sided inattention, and an enhanced response to methylphenidate in attention-deficit hyperactivity disorder
Journal name Neuropsychopharmacology   Check publisher's open access policy
ISSN 0893-133X
Publication date 2005
Sub-type Article (original research)
DOI 10.1038/sj.npp.1300839
Volume 30
Issue 12
Start page 2290
End page 2297
Total pages 8
Place of publication London
Publisher Nature Publishing Group
Language eng
Subject 1701 Psychology
Abstract A polymorphism of the dopamine transporter gene (DAT1, 10-repeat) is associated with attention-deficit hyperactivity disorder (ADHD) and has been linked to an enhanced response to methylphenidate (MPH). One aspect of the attention deficit in ADHD includes a subtle inattention to left space, resembling that seen after right cerebral hemisphere damage. Since left-sided inattention in ADHD may resolve when treated with MPH, we asked whether left-sided inattention in ADHD was related to DAT1 genotype and the therapeutic efficacy of MPH. A total of 43 ADHD children and their parents were genotyped for the DAT1 30 variable number of tandem repeats polymorphism. The children performed the Landmark Test, a well-validated measure yielding a spatial attentional asymmetry index ( leftward to rightward attentional bias). Parents rated their child's response to MPH retrospectively using a three-point scale ( no, mediocre or very good response). Additionally, parents used a symptom checklist to rate behavior while on and off medication. A within-family control design determined whether asymmetry indices predicted biased transmission of 10-repeat parental DAT1 alleles and/or response to MPH. It was found that left-sided inattention predicted transmission of the 10-repeat allele from parents to probands and was associated with the severity of ADHD symptomatology. Children rated as achieving a very good response to MPH displayed left-sided inattention, while those rated as achieving a poorer response did not. Our results suggest a subgroup of children with ADHD for whom the 10-repeat DAT1 allele is associated with left-sided inattention. MPH may be most efficacious in this group because it ameliorates a DAT1-mediated hypodopaminergic state.
Keyword Neurosciences
Pharmacology & Pharmacy
Psychiatry
Dati
Dopamine
Adhd
Methylphenidate
Attention
Genetics
Functional Magnetic-resonance
Visual-spatial Attention
Deficit/hyperactivity Disorder
7-repeat Allele
Basal Ganglia
Children
Gene
Performance
Polymorphism
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
Queensland Brain Institute Publications
School of Psychology Publications
 
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Created: Mon, 13 Aug 2007, 15:41:56 EST