HRT and breast cancer: Impact on population risk and incidence

Coombes, Nathan J., Taylor, Richard, Wilcken, Nicholas and Boyages, John (2005) HRT and breast cancer: Impact on population risk and incidence. European Journal of Cancer, 41 12: 1775-1781. doi:10.1016/j.ejca.2005.03.030

Author Coombes, Nathan J.
Taylor, Richard
Wilcken, Nicholas
Boyages, John
Title HRT and breast cancer: Impact on population risk and incidence
Journal name European Journal of Cancer   Check publisher's open access policy
ISSN 0959-8049
Publication date 2005
Sub-type Article (original research)
DOI 10.1016/j.ejca.2005.03.030
Volume 41
Issue 12
Start page 1775
End page 1781
Total pages 7
Place of publication Oxford, United Kingdom
Publisher Pergamon
Language eng
Subject 320000 Medical and Health Sciences
11 Medical and Health Sciences
1112 Oncology and Carcinogenesis
Abstract This study has calculated the potential impact of hormone replacement therapy (HRT) on breast cancer incidence in Australia and has estimated how changes in prescribing HRT to women could affect this risk. The effects of HRT on breast cancer incidence was estimated using the attributable fraction technique with prevalence data derived from the 2001 Australian Health Survey and published rates of breast cancer relative risks from HRT use. In Australia, 12% of adult women were current HRT users and in 2001, 11783 breast cancers were reported. Of these, 1066 (9%) were potentially attributable to HRT. Restricting HRT use to women aged less than 65 years, ceasing HRT prescribing after 10 years or limiting combined oestrogen and progesterone HRT to five years (but otherwise keeping prescription levels to 2001 levels) may reduce the annual breast cancer caseload by 280 (2.4%), 555 (4.7%) or 674 (5.7%), respectively. In conclusion, this study has demonstrated that when HRT prevalence is relatively high, the effect on breast cancer incidence in the population will be significant. A small modification in HRT prescribing practices may impact breast cancer incidence in Australia with associated financial and health care provision implications. (C) 2005 Elsevier Ltd. All rights reserved.
Keyword Oncology
Breast Cancer
Hormone Replacement Therapy
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Public Health Publications
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 17 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 24 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Mon, 13 Aug 2007, 15:30:19 EST