Development of a human cardiac organoid injury model reveals innate regenerative potential

Voges, Holly K. , Mills, Richard J., Elliott, David A., Parton, Robert G. , Porrello, Enzo R. and Hudson, James E. (2017) Development of a human cardiac organoid injury model reveals innate regenerative potential. Development , 144 6: 1118-1127. doi:10.1242/dev.143966


Author Voges, Holly K.
Mills, Richard J.
Elliott, David A.
Parton, Robert G.
Porrello, Enzo R.
Hudson, James E.
Title Development of a human cardiac organoid injury model reveals innate regenerative potential
Journal name Development    Check publisher's open access policy
ISSN 1477-9129
0950-1991
Publication date 2017-03-01
Sub-type Article (original research)
DOI 10.1242/dev.143966
Open Access Status Not yet assessed
Volume 144
Issue 6
Start page 1118
End page 1127
Total pages 10
Place of publication Cambridge, United Kingdom
Publisher Company of Biologists
Collection year 2018
Language eng
Abstract The adult human heart possesses a limited regenerative potential following an ischemic event, and undergoes a number of pathological changes in response to injury. Although cardiac regeneration has been documented in zebrafish and neonatal mouse hearts, it is currently unknown whether the immature human heart is capable of undergoing complete regeneration. Combined progress in pluripotent stem cell differentiation and tissue engineering has facilitated the development of human cardiac organoids (hCOs), which resemble fetal heart tissue and can be used to address this important knowledge gap. This study aimed to characterize the regenerative capacity of immature human heart tissue in response to injury. Following cryoinjury with a dry ice probe, hCOs exhibited an endogenous regenerative response with full functional recovery 2 weeks after acute injury. Cardiac functional recovery occurred in the absence of pathological fibrosis or cardiomyocyte hypertrophy. Consistent with regenerative organisms and neonatal human hearts, there was a high basal level of cardiomyocyte proliferation, which may be responsible for the regenerative capacity of the hCOs. This study suggests that immature human heart tissue has an intrinsic capacity to regenerate.
Keyword Cardiac organoids
Cardiac tissue engineering
Injury model
Regeneration
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

 
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