Curvilinear telomere length dynamics in a squamate reptile

Ujvari, Beata, Biro, Peter A., Charters, Jordan E. , Brown, Gregory, Heasman, Kim, Beckmann, Christa and Madsen, Thomas (2017) Curvilinear telomere length dynamics in a squamate reptile. Functional Ecology, 31 3: 753-759. doi:10.1111/1365-2435.12764


Author Ujvari, Beata
Biro, Peter A.
Charters, Jordan E.
Brown, Gregory
Heasman, Kim
Beckmann, Christa
Madsen, Thomas
Title Curvilinear telomere length dynamics in a squamate reptile
Journal name Functional Ecology   Check publisher's open access policy
ISSN 1365-2435
0269-8463
Publication date 2017-03-01
Year available 2016
Sub-type Article (original research)
DOI 10.1111/1365-2435.12764
Open Access Status Not yet assessed
Volume 31
Issue 3
Start page 753
End page 759
Total pages 7
Place of publication Chichester, West Sussex, United Kingdom
Publisher Wiley-Blackwell Publishing
Collection year 2018
Language eng
Formatted abstract
The lack of consensus concerning the impact of telomere length (TL) dynamics on survival emphasizes the need for additional studies to evaluate the effect of TL on key life-history processes. Using both cross-sectional and longitudinal data, we therefore explored age-specific TL dynamics in a squamate reptile: the frillneck lizard (Chlamydosaurus kingii). Our cross-sectional analyses revealed that young lizards had short TL, TL increased in medium-aged lizards, but TL decreased in older age cohorts, revealing a curvilinear relationship between TL and frillneck lizard age. Neither our cross-sectional nor our longitudinal analyses revealed any association between TL dynamics and lizard survival. We observed a significant positive relationship between TL and telomerase expression (TE), suggesting that TE is a significant determinant of frillneck lizard TL dynamics. Importantly, our longitudinal analyses revealed a positive relationship between initial TL and telomere attrition rate within individual lizards, that is lizards with short initial telomeres were subjected to reduced telomere attrition rates compared to lizards with long initial TL. Our results strongly suggest that TL and TE dynamics in frillneck lizards is not associated with lizard survival but rather reflect an adaptation to maintain TL above a critical minimum length in order to sustain cellular homeostasis. A lay summary is available for this article.
Keyword Cellular homeostasis
Frillneck lizard
Survival
Telomerase expression
Telomere length dynamics
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
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