Microstructural and functional correlates of glutamate concentration in the posterior cingulate cortex

Arrubla, Jorge, Farrher, Ezequiel, Strippelmann, Johanna, Tse, Desmond H. Y., Grinberg, Farida, Shah, N. Jon and Neuner, Irene (2017) Microstructural and functional correlates of glutamate concentration in the posterior cingulate cortex. Journal of Neuroscience Research, . doi:10.1002/jnr.24010


Author Arrubla, Jorge
Farrher, Ezequiel
Strippelmann, Johanna
Tse, Desmond H. Y.
Grinberg, Farida
Shah, N. Jon
Neuner, Irene
Title Microstructural and functional correlates of glutamate concentration in the posterior cingulate cortex
Journal name Journal of Neuroscience Research   Check publisher's open access policy
ISSN 0360-4012
1097-4547
Publication date 2017-01-24
Year available 2017
Sub-type Article (original research)
DOI 10.1002/jnr.24010
Open Access Status Not yet assessed
Total pages 13
Place of publication Hoboken, NJ, United States
Publisher John Wiley & Sons
Collection year 2018
Language eng
Formatted abstract
Glutamate is the major excitatory neurotransmitter in the human brain and has a central role in both intrinsic and stimulus-induced activity. We conducted a study in a cohort of healthy, male volunteers in which glutamate levels were measured in the posterior cingulate cortex (PCC) using 1H magnetic resonance spectroscopy at 3T. The advantages of simultaneous electroencephalography and magnetic resonance imaging (EEG-MRI) were exploited and the subjects were measured in the same session and under the same physiological conditions. Diffusion tensor imaging (DTI), functional MRI (fMRI) and EEG were measured in order to investigate the functional and microstructural correlates of glutamate. The concentration of glutamate (institute units) was calculated and those values were tested for correlation with the metrics of resting state fMRI, DTI, and EEG electrical sources. Our results showed that the concentration of glutamate in the PCC had a significant negative correlation with the tissue mean diffusivity in the same area. The analysis of resting state networks did not show any relationship between the concentration of glutamate and the intrinsic activity of the resting state networks. The concentration of glutamate showed a positive correlation with the electrical generators of α–1 frequency and a negative correlation with the generators of α–2 and β–1 electrical generators.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Centre for Advanced Imaging Publications
 
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Created: Mon, 20 Mar 2017, 14:46:18 EST by Ms Kate Rowe on behalf of Learning and Research Services (UQ Library)