The influence of the microbiome on early-life severe viral lower respiratory infections and asthma-food for thought?

Lynch, Jason P., Sikder, Al Amin, Curren, Bodie F., Werder, Rhiannon B., Simpson, Jennifer, Cuiv, Paraic O., Dennis, Paul G., Everard, Mark L. and Phipps, Simon (2017) The influence of the microbiome on early-life severe viral lower respiratory infections and asthma-food for thought?. Frontiers in Immunology, 8 . doi:10.3389/fimmu.2017.00156


Author Lynch, Jason P.
Sikder, Al Amin
Curren, Bodie F.
Werder, Rhiannon B.
Simpson, Jennifer
Cuiv, Paraic O.
Dennis, Paul G.
Everard, Mark L.
Phipps, Simon
Title The influence of the microbiome on early-life severe viral lower respiratory infections and asthma-food for thought?
Journal name Frontiers in Immunology   Check publisher's open access policy
ISSN 1664-3224
Publication date 2017-02-16
Sub-type Critical review of research, literature review, critical commentary
DOI 10.3389/fimmu.2017.00156
Open Access Status DOI
Volume 8
Total pages 15
Place of publication Lausanne, Switzerland
Publisher Frontiers Research Foundation
Collection year 2018
Language eng
Abstract Severe viral lower respiratory infections are a major cause of infant morbidity. In developing countries, respiratory syncytial virus (RSV)-bronchiolitis induces significant mortality, whereas in developed nations the disease represents a major risk factor for subsequent asthma. Susceptibility to severe RSV-bronchiolitis is governed by gene-environmental interactions that affect the host response to RSV infection. Emerging evidence suggests that the excessive inflammatory response and ensuing immunopathology, typically as a consequence of insufficient immunoregulation, leads to long-term changes in immune cells and structural cells that render the host susceptible to subsequent environmental incursions. Thus, the initial host response to RSV may represent a tipping point in the balance between long-term respiratory health or chronic disease (e.g., asthma). The composition and diversity of the microbiota, which in humans stabilizes in the first year of life, critically affects the development and function of the immune system. Hence, perturbations to the maternal and/or infant microbiota are likely to have a profound impact on the host response to RSV and susceptibility to childhood asthma. Here, we review recent insights describing the effects of the microbiota on immune system homeostasis and respiratory disease and discuss the environmental factors that promote microbial dysbiosis in infancy. Ultimately, this knowledge will be harnessed for the prevention and treatment of severe viral bronchiolitis as a strategy to prevent the onset and development of asthma.
Keyword Asthma
Microbiome
Microbiota
Microbiota and immunity
PVM
RSV
Viral lower respiratory tract infection
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: HERDC Pre-Audit
School of Agriculture and Food Sciences
School of Biomedical Sciences Publications
UQ Diamantina Institute Publications
 
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