An injectable in-situ conducting thermosensitive gel for controlled delivery of vancomycin in osteomyelitis treatment and bone regeneration

Aparna, R. S. L., Prasad, R. G. S. V. and Nirmal, Nilesh Prakash (2016) An injectable in-situ conducting thermosensitive gel for controlled delivery of vancomycin in osteomyelitis treatment and bone regeneration. Science of Advanced Materials, 8 7: 1470-1477. doi:10.1166/sam.2016.2691


Author Aparna, R. S. L.
Prasad, R. G. S. V.
Nirmal, Nilesh Prakash
Title An injectable in-situ conducting thermosensitive gel for controlled delivery of vancomycin in osteomyelitis treatment and bone regeneration
Formatted title
An injectable in-situ conducting thermosensitive gel for controlled delivery of vancomycin in osteomyelitis treatment and bone regeneration
Journal name Science of Advanced Materials   Check publisher's open access policy
ISSN 1947-2943
1947-2935
Publication date 2016-07-01
Year available 2016
Sub-type Article (original research)
DOI 10.1166/sam.2016.2691
Open Access Status Not yet assessed
Volume 8
Issue 7
Start page 1470
End page 1477
Total pages 8
Place of publication Valencia, CA, United States
Publisher American Scientific Publishers
Collection year 2017
Language eng
Formatted abstract
A novel injectable, conductive and thermosensitive gel composed of chitosan/chitosan grafted polyaniline (Chi-g-PANI) was synthesized. The prepared gels were characterized by scanning electron microscopy (SEM) showed a porous, interconnecting and netlike architecture. The conductivity of chitosan and Chi-g-PANI incorporated gels were 11.45 ± 2.67 and 49.76 ± 3.56 μS, respectively (P < 0.05). Both gels showed sustained release of vancomycin (67.87 ± 1.31 for chitosan gel; 65.78 ± 1.93 for Chi-g-PANI incorporated gel) over a period of 28 days. Cytotoxicity and LDH activity investigations indicated the nontoxic nature of the gels. In vitro cell culture was performed by using MC3T3-E1and C2C12 cells which indicated that these gels were suitable for cellular attachment and proliferation. Primary osteogenic markers, like ALP and calcium production, were enhanced when MC3T3-E1 cells were cultured along with the gels. Thus, these results indicate that the synthesized gels could be a promising injectable material for osteomyelitis (OM) treatment and bone regeneration.
Keyword Conductive Gels
Osteogenic Efficiency
Osteomyelitis
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Centre for Nutrition and Food Sciences Publications
 
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