GABA concentration in posterior cingulate cortex predicts putamen response during resting state fMRI

Arrubla, Jorge, Tse, Desmond H. Y., Amkreutz, Christin, Neuner, Irene and Shah, N. Jon (2014) GABA concentration in posterior cingulate cortex predicts putamen response during resting state fMRI. Plos One, 9 9: . doi:10.1371/journal.pone.0106609


Author Arrubla, Jorge
Tse, Desmond H. Y.
Amkreutz, Christin
Neuner, Irene
Shah, N. Jon
Title GABA concentration in posterior cingulate cortex predicts putamen response during resting state fMRI
Journal name Plos One   Check publisher's open access policy
ISSN 1932-6203
Publication date 2014-09-03
Sub-type Article (original research)
DOI 10.1371/journal.pone.0106609
Open Access Status DOI
Volume 9
Issue 9
Total pages 7
Place of publication San Francisco, CA, United States
Publisher Public Library of Science
Language eng
Abstract The role of neurotransmitters in the activity of resting state networks has been gaining attention and has become a field of research with magnetic resonance spectroscopy (MRS) being one of the key techniques. MRS permits the measurement of γ-aminobutyric acid (GABA) and glutamate levels, the central biochemical constituents of the excitation-inhibition balance in vivo. The inhibitory effects of GABA in the brain have been largely investigated in relation to the activity of resting state networks in functional magnetic resonance imaging (fMRI). In this study GABA concentration in the posterior cingulate cortex (PCC) was measured using single voxel spectra acquired with standard point resolved spectroscopy (PRESS) from 20 healthy male volunteers at 3 T. Resting state fMRI was consecutively measured and the values of GABA/Creatine+ Phosphocreatine ratio (GABA ratio) were included in a general linear model matrix as a step of dual regression analysis in order to identify voxels whose neuroimaging metrics during rest were related to individual levels of the GABA ratio. Our data show that the connection strength of putamen to the default-mode network during resting state has a negative linear relationship with the GABA ratio measured in the PCC. These findings highlight the role of PCC and GABA in segregation of the motor input, which is an inherent condition that characterises resting state.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Centre for Advanced Imaging Publications
 
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