Therapeutic vaccination against HIV: Current progress and future possibilities

Puls, R.L. and Emery, S. (2005) Therapeutic vaccination against HIV: Current progress and future possibilities. Clinical Science, 110 1: 59-71. doi:10.1042/CS20050157


Author Puls, R.L.
Emery, S.
Title Therapeutic vaccination against HIV: Current progress and future possibilities
Journal name Clinical Science   Check publisher's open access policy
ISSN 0143-5221
Publication date 2005-12-12
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1042/CS20050157
Open Access Status Not yet assessed
Volume 110
Issue 1
Start page 59
End page 71
Total pages 13
Place of publication London, United Kingdom
Publisher Portland Press
Language eng
Formatted abstract
Although effective in reducing mortality, current antiretroviral therapy for HIV infection involves complex and expensive drug regimens that are toxic and difficult to take. Eradication of HIV reservoirs is not possible with existing therapies. The concept of therapeutic vaccination has been investigated to increase the potency and breadth of anti-HIV immune responses in order to delay or reduce antiretroviral therapy use. A variety of approaches targeted to both cell- and antibody-mediated immunity have been developed, including whole inactivated HIV-1, protein subunits and synthetic peptides, DNA vaccines and a number of viral vectors expressing HIV-1. These investigations have occurred in the absence of a clear understanding of disease pathogenesis or the correlates of protective immunity. At this time, there is no licensed therapeutic vaccine for any viral disease, including HIV; however, this review will consider recent progress in the field and summarize the challenges faced in the development of a therapeutic HIV vaccine.
Keyword Cellular immunity
HIV
Humoral immunity
Structured treatment interruption
Therapeutic vaccine
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: School of Medicine Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 11 times in Thomson Reuters Web of Science Article | Citations
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