The search for an HIV cure: Tackling latent infection

Kent, Stephen J., Reece, Jeanette C., Petravic, Janka, Martyushev, Alexey, Kramski, Marit, De Rose, Robert, Cooper, David A., Kelleher, Anthony D., Emery, Sean, Cameron, Paul U., Lewin, Sharon R. and Davenport, Miles P. (2013) The search for an HIV cure: Tackling latent infection. Lancet Infectious Diseases, 13 7: 614-621. doi:10.1016/S1473-3099(13)70043-4


Author Kent, Stephen J.
Reece, Jeanette C.
Petravic, Janka
Martyushev, Alexey
Kramski, Marit
De Rose, Robert
Cooper, David A.
Kelleher, Anthony D.
Emery, Sean
Cameron, Paul U.
Lewin, Sharon R.
Davenport, Miles P.
Title The search for an HIV cure: Tackling latent infection
Journal name Lancet Infectious Diseases   Check publisher's open access policy
ISSN 1473-3099
Publication date 2013-07-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/S1473-3099(13)70043-4
Open Access Status Not yet assessed
Volume 13
Issue 7
Start page 614
End page 621
Total pages 8
Place of publication London, United Kingdom
Publisher The Lancet Publishing Group
Language eng
Formatted abstract
Strategies to eliminate infectious HIV that persists despite present treatments and with the potential to cure HIV infection are of great interest. One patient seems to have been cured of HIV infection after receiving a bone marrow transplant with cells resistant to the virus, although this strategy is not viable for large numbers of infected people. Several clinical trials are underway in which drugs are being used to activate cells that harbour latent HIV. In a recent study, investigators showed that activation of latent HIV infection in patients on antiretroviral therapy could be achieved with a single dose of vorinostat, a licensed anticancer drug that inhibits histone deacetylase. Although far from a cure, such studies provide some guidance towards the logical next steps for research. Clinical studies that use a longer duration of drug dosing, alternative agents, combination approaches, gene therapy, and immune-modulation approaches are all underway.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: School of Medicine Publications
 
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