Current developments in regenerative endodontics

Kim, Sahng G., Kahler, Bill and Lin, Louis M. (2016) Current developments in regenerative endodontics. Current Oral Health Reports, 3 4: 293-301. doi:10.1007/s40496-016-0109-8


Author Kim, Sahng G.
Kahler, Bill
Lin, Louis M.
Title Current developments in regenerative endodontics
Journal name Current Oral Health Reports   Check publisher's open access policy
ISSN 2196-3002
Publication date 2016-12-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1007/s40496-016-0109-8
Open Access Status Not yet assessed
Volume 3
Issue 4
Start page 293
End page 301
Total pages 9
Place of publication Heidelberg, Germany
Publisher Springer
Collection year 2017
Language eng
Abstract This review outlines the biological basis and clinical protocols used currently in regenerative endodontic procedures and discusses future directions in pulp regeneration appraches. Since the discovery of dental stem cells capable of differentiating into odontoblast-like cells and revascularization/regenerative endodontic therapy with the potential of promoting thickening of the canal walls and continued root development of immature permanent teeth with necrotic pulps, the study of pulp tissue engineering or pulp tissue regeneration has taken a giant step forward in biological and clinical endodontics. The biological concept of regenerative endodontics involves the triad of stem cells, scaffold, and signaling molecules. In preclinical studies, researchers are looking for mesenchymal stem cells not only capable of differentiating into odontoblast-like cells but also highly angiogenic/vasculogenic and neurogenic for complete pulp regeneration. Tremendous efforts are also dedicated to search for three-dimensional biomimetic scaffolds to enhance stem cell migration, adhesion, proliferation, and differentiation as well as tissue structure support. In clinical trials, besides immature permanent teeth with necrotic pulp, regenerative endodontic therapy has been employed to treat mature permanent teeth with necrotic pulps, teeth with persistent apical periodontitis after primary root canal therapy, and traumatized teeth associated horizontal root fractures, root resorption, and avulsion.
Keyword Dental stem cells
Immature teeth
Necrotic pulps
Pulp tissue regeneration
Regenerative endodontics
Revascularization
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: HERDC Pre-Audit
School of Dentistry Publications
 
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Created: Thu, 16 Mar 2017, 14:54:20 EST by Jackie Devenish on behalf of Learning and Research Services (UQ Library)