Effects of different exercise modalities on fatigue in prostate cancer patients undergoing androgen deprivation therapy: a year-long randomised controlled trial

Taaffe, Dennis R., Newton, Robert U., Spry, Nigel, Joseph, David, Chambers, Suzanne K., Gardiner, Robert A., Wall, Brad A., Cormie, Prue, Bolam, Kate A. and Galvao, Daniel A. (2017) Effects of different exercise modalities on fatigue in prostate cancer patients undergoing androgen deprivation therapy: a year-long randomised controlled trial. European Urology, . doi:10.1016/j.eururo.2017.02.019


Author Taaffe, Dennis R.
Newton, Robert U.
Spry, Nigel
Joseph, David
Chambers, Suzanne K.
Gardiner, Robert A.
Wall, Brad A.
Cormie, Prue
Bolam, Kate A.
Galvao, Daniel A.
Title Effects of different exercise modalities on fatigue in prostate cancer patients undergoing androgen deprivation therapy: a year-long randomised controlled trial
Journal name European Urology   Check publisher's open access policy
ISSN 1873-7560
0302-2838
Publication date 2017-02-27
Sub-type Article (original research)
DOI 10.1016/j.eururo.2017.02.019
Open Access Status DOI
Total pages 7
Place of publication Amsterdam, Netherlands
Publisher Elsevier BV
Collection year 2018
Language eng
Formatted abstract
Background: Physical exercise mitigates fatigue during androgen deprivation therapy (ADT); however, the effects of different exercise prescriptions are unknown.

Objectives: To determine the long-term effects of different exercise modes on fatigue in prostate cancer patients undergoing ADT.

Design, setting, and participants: Between 2009 and 2012, 163 prostate cancer patients aged 43-90 y on ADT were randomised to exercise targeting the musculoskeletal system (impact loading + resistance training; ILRT; n = 58), the cardiovascular and muscular systems (aerobic + resistance training; ART; n = 54), or to usual care/delayed exercise (DEL; n = 51) for 12 mo across university-affiliated exercise clinics in Australia.

Intervention: Supervised ILRT for 12 mo, supervised ART for 6 mo followed by a 6-mo home program, and DEL received a printed booklet on exercise information for 6 mo followed by 6-mo stationary cycling exercise.

Outcome measurements and statistical analysis: Fatigue was assessed using the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire-Core 36 and vitality using the Short Form-36. Analysis of variance was used to compare outcomes for groups at 6 mo and 12 mo.

Results and limitations: Fatigue was reduced (p =0.005) in ILRT at 6 mo and 12 mo (∼5 points), and in ART (p =0.005) and DEL (p =0.022) at 12 mo. Similarly, vitality increased for all groups (p ≤0.001) at 12 mo (∼4 points). Those with the highest levels of fatigue and lowest vitality improved the most with exercise (ptrend <0.001). A limitation was inclusion of mostly well-functioning individuals.

Conclusions: Different exercise modes have comparable effects on reducing fatigue and enhancing vitality during ADT. Patients with the highest levels of fatigue and lowest vitality had the greatest benefits.

Patient summary: We compared the effects of different exercise modes on fatigue in men on androgen deprivation therapy. All exercise programs reduced fatigue and enhanced vitality. We conclude that undertaking some form of exercise will help reduce fatigue, especially in those who are the most fatigued. We compared the effects of different exercise modes on fatigue in men on androgen deprivation therapy. All exercise programs reduced fatigue and enhanced vitality. We conclude that undertaking some form of exercise will help reduce fatigue, especially in those who are the most fatigued.
Keyword Aerobic exercise
Androgen deprivation therapy
Exercise
Exercise prescription
Fatigue
Prostate cancer
Resistance exercise
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
HERDC Pre-Audit
School of Human Movement and Nutrition Sciences Publications
 
Versions
Version Filter Type
Citation counts: Scopus Citation Count Cited 0 times in Scopus Article
Google Scholar Search Google Scholar
Created: Tue, 14 Mar 2017, 00:24:17 EST by System User on behalf of Learning and Research Services (UQ Library)