Susceptibility to non-tuberculous mycobacterial disease is influenced by rs1518111 in IL10

Halstrom, Samuel, Thomson, Rachel, Goullee, Hayley, Baltic, Svetlana, Allcock, Richard, Temple, Suzanna E. L. and Price, Patricia (2017) Susceptibility to non-tuberculous mycobacterial disease is influenced by rs1518111 in IL10. Human Immunology, . doi:10.1016/j.humimm.2017.02.001


Author Halstrom, Samuel
Thomson, Rachel
Goullee, Hayley
Baltic, Svetlana
Allcock, Richard
Temple, Suzanna E. L.
Price, Patricia
Title Susceptibility to non-tuberculous mycobacterial disease is influenced by rs1518111 in IL10
Journal name Human Immunology   Check publisher's open access policy
ISSN 0198-8859
1879-1166
Publication date 2017-01-01
Year available 2017
Sub-type Article (original research)
DOI 10.1016/j.humimm.2017.02.001
Open Access Status Not yet assessed
Total pages 3
Place of publication Philadelphia, PA United States
Publisher Elsevier
Formatted abstract
Although exposure to potentially pathogenic nontuberculous mycobacteria (NTM) via soil and domestic
water supplies is common, pulmonary infection and disease are confined to a small proportion of older
individuals. Previously, alleles of a polymorphism in IL10 (rs1800896) were associated with NTM disease
and we demonstrated elevated production of IL-10 by blood leukocytes from patients with pulmonary
NTM. Here seven additional polymorphisms in IL10 were investigated in a larger cohort of Caucasian controls
and patients with pulmonary NTM disease. This demonstrated a significant association between
pulmonary NTM disease and one polymorphism (rs1518111) in strong linkage disequilibrium with
rs1800896.
Keyword Genetic polymorphism
IL10
Nontuberculous mycobacteria
Pulmonary disease
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
School of Medicine Publications
 
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