The application of self-assembled nanostructures in peptide-based subunit vaccine development

Zhao, Guangzu, Chandrudu, Saranya, Skwarczynski, Mariusz and Toth, Istvan (2017) The application of self-assembled nanostructures in peptide-based subunit vaccine development. European Polymer Journal, . doi:10.1016/j.eurpolymj.2017.02.014


Author Zhao, Guangzu
Chandrudu, Saranya
Skwarczynski, Mariusz
Toth, Istvan
Title The application of self-assembled nanostructures in peptide-based subunit vaccine development
Journal name European Polymer Journal   Check publisher's open access policy
ISSN 0014-3057
1873-1945
Publication date 2017-02-10
Sub-type Article (original research)
DOI 10.1016/j.eurpolymj.2017.02.014
Open Access Status Not yet assessed
Total pages 12
Place of publication Kidlington, Oxford, United Kingdom
Publisher Pergamon Press
Collection year 2018
Language eng
Abstract Peptide based-vaccines are becoming one of the most widely investigated prophylactic and therapeutic health care interventions against a variety of diseases, including cancer. However, the lack of a safe and highly efficient adjuvant (immune stimulant) is regarded as the biggest obstacle to vaccine development. The incorporation of a peptide antigen in a nanostructure-based delivery system was recently shown to overcome this obstacle. Nanostructures are often formed from antigens conjugated to molecules such as polymers, lipids, and peptide, with the help of self-assembly phenomenon. This review describes the application of self-assembly process for the production of peptide-based vaccine candidates and the ability of these nanostructures to stimulate humoral and cellular immune responses.
Keyword Conjugation
Lipopeptide
Nanofiber
Nanoparticle
Polymer
Self-assembly
Vaccine
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

 
Versions
Version Filter Type
Citation counts: Scopus Citation Count Cited 0 times in Scopus Article
Google Scholar Search Google Scholar
Created: Tue, 07 Mar 2017, 00:20:21 EST by System User on behalf of Learning and Research Services (UQ Library)