Multidrug resistance in glioblastoma stem-like cells: role of the hypoxic microenvironment and adenosine signaling

Uribe, Daniel, Torres, Angelo, Rocha, Jose Dellis , Niechi, Ignacio, Oyarzun, Carlos, Sobrevia, Luis, San Martin, Rody and Quezada, Claudia (2017) Multidrug resistance in glioblastoma stem-like cells: role of the hypoxic microenvironment and adenosine signaling. Molecular Aspects of Medicine, . doi:10.1016/j.mam.2017.01.009


Author Uribe, Daniel
Torres, Angelo
Rocha, Jose Dellis
Niechi, Ignacio
Oyarzun, Carlos
Sobrevia, Luis
San Martin, Rody
Quezada, Claudia
Title Multidrug resistance in glioblastoma stem-like cells: role of the hypoxic microenvironment and adenosine signaling
Journal name Molecular Aspects of Medicine   Check publisher's open access policy
ISSN 1872-9452
0098-2997
Publication date 2017-02-20
Sub-type Article (original research)
DOI 10.1016/j.mam.2017.01.009
Open Access Status Not yet assessed
Total pages 12
Place of publication Kidlington, Oxford, United Kingdom
Publisher Pergamon Press
Collection year 2018
Language eng
Abstract Glioblastoma multiforme (GBM) is considered the most common and aggressive tumour of the central nervous system and is characterized for being highly chemoresistant. This property is mainly due to the activation of Multiple Drug Resistance (MDR) mechanisms that protect cancer cells from structurally and morphologically different drugs. Overexpression and increased ABC transporters activity is one of the most important MDR mechanisms at the clinical level, and both its expression and activity are elevated in GBM cells. Within the tumour, there is a subpopulation called glioblastoma stem-like cells (GSCs), which due to its high tumourigenic capacity and chemoresistance, have been postulated as the main responsible for tumour recurrence. The GSCs inhabit hypoxic tumour zones, niches that apart from maintaining and promoting stem phenotype have also been correlated with high chemoresistance. Of the signalling pathways activated during hypoxia, purinergic signalling has been highly associated to the induction of MDR mechanisms. Through its receptors, the nucleoside adenosine has been shown to promotes the chemoresistance mediated by ABC transporters. Therefore, targeting its components is a promising alternative for GBM treatment. In this review, we will discuss chemoresistance in GSCs and the effect of the hypoxic microenvironment and adenosine on MDR mechanisms.
Keyword Adenosine
ATP-Binding Cassette (ABC) transporter
Glioblastoma multiforme
Glioblastoma stem-like cells
Hypoxia
Multiple Drug Resistance
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
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