Atheroprotective effects and molecular targets of tanshinones derived from herbal medicine Danshen

Fang, Jian, Little, Peter J. and Xu, Suowen (2017) Atheroprotective effects and molecular targets of tanshinones derived from herbal medicine Danshen. Medicinal Research Reviews, . doi:10.1002/med.21438


Author Fang, Jian
Little, Peter J.
Xu, Suowen
Title Atheroprotective effects and molecular targets of tanshinones derived from herbal medicine Danshen
Journal name Medicinal Research Reviews   Check publisher's open access policy
ISSN 1098-1128
0198-6325
Publication date 2017-02-16
Sub-type Article (original research)
DOI 10.1002/med.21438
Open Access Status Not yet assessed
Total pages 28
Place of publication Hoboken, NJ, United States
Publisher John Wiley & Sons
Collection year 2018
Language eng
Formatted abstract
Medicinal plant-derived bioactive compounds modulate multiple therapeutic targets in cardiovascular diseases (CVDs), rendering herb-derived phytochemicals effective against one of the major CVDs-atherosclerosis. Danshen (Salvia milthiorriza Bunge) is a Chinese medicine that has been used in cardio- and cerebro-vascular therapeutic remedies in Asian countries for many years. Emerging evidence from cellular, animal, and clinical studies suggests that major lipophilic tanshinones from Danshen can treat atherosclerotic CVDs. In this review, we highlight recent advances in understanding the molecular mechanisms of tanshinones in treating atherosclerosis, ranging from endothelial dysfunction to chronic inflammation. We also overview new molecular targets of tanshinones, including endothelial nitric oxide synthase, AMP-activated protein kinase, ABC transporter A1, heme oxygenase 1, soluble epoxide hydrolase, 11β-hydroxysteroid dehydrogenase, estrogen receptor, and proprotein convertase subtilisin/kexin type 9. Thus, this review provides a new perspective for advancing our understanding of the "ancient" herb Danshen from "modern" biomedical perspectives, supporting the possibility of exploiting tanshinones and derivatives as effective therapeutics against atherosclerosis-related cardiovascular and metabolic diseases.
Keyword Atherosclerosis
Danshen
Drug discovery
Tanshinone
Target
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
School of Pharmacy Publications
 
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