Highly pathogenic avian influenza (H5N1) virus in feathers: tropism and pathology of virus-infected feathers of infected ducks and chickens

Nuradji, H., Bingham, J., Payne, J., Harper, J., Lowther, S., Wibawa, H., Long, N. T. and Meers, J. (2017) Highly pathogenic avian influenza (H5N1) virus in feathers: tropism and pathology of virus-infected feathers of infected ducks and chickens. Veterinary Pathology, 54 2: 226-233. doi:10.1177/0300985816666608


Author Nuradji, H.
Bingham, J.
Payne, J.
Harper, J.
Lowther, S.
Wibawa, H.
Long, N. T.
Meers, J.
Title Highly pathogenic avian influenza (H5N1) virus in feathers: tropism and pathology of virus-infected feathers of infected ducks and chickens
Journal name Veterinary Pathology   Check publisher's open access policy
ISSN 1544-2217
0300-9858
Publication date 2017-03-01
Sub-type Article (original research)
DOI 10.1177/0300985816666608
Open Access Status Not yet assessed
Volume 54
Issue 2
Start page 226
End page 233
Total pages 8
Place of publication Thousand Oaks, CA, United States
Publisher Sage Publications
Collection year 2018
Language eng
Abstract H5N1 highly pathogenic avian influenza (HPAI) virus causes high mortality of infected birds, with infection in multiple organs, including in feathers. Feathers have been proposed as samples for diagnosis of HPAI infection in birds, and this study is part of a broader investigation validating the use of feathers for diagnostic purposes. To understand and characterize the morphological basis for feather infection, sections from 7 different skin tracts of ducks and chickens infected with 3 different clades of H5N1 HPAI virus from Indonesia and Vietnam were examined histologically. Results showed that in ducks, lesions and viral antigen were mainly detected in the epidermis of feathers and follicles, whereas in chickens, they were mostly found in the dermis of these structures. Abundant viral antigen was found in nearly all the feathers examined from chickens, and there was no apparent difference between virus isolates or skin tracts in the proportion of feathers that were antigen positive. By immunohistochemistry, the majority of feathers from most skin tracts from ducks infected with a Vietnamese H5N1 HPAI virus contained abundant levels of viral antigen, while few feathers were antigen positive from ducks infected with 2 Indonesian viruses. These results support and inform the use of feathers for diagnostic detection of H5N1 HPAI virus in birds.
Keyword Chicken
Duck
Feathers
H5N1
Highly pathogenic avian influenza
Skin
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
School of Veterinary Science Publications
 
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