Weight loss independent association of TCF7 L2 gene polymorphism with fasting blood glucose after Roux-en-Y gastric bypass in type 2 diabetic patients

Rouskas, Konstantinos, Cauchi, Stephane, Raverdy, Violeta, Yengo, Loic, Froguel, Philippe and Pattou, Francois (2014) Weight loss independent association of TCF7 L2 gene polymorphism with fasting blood glucose after Roux-en-Y gastric bypass in type 2 diabetic patients. Surgery for Obesity and Related Diseases, 10 4: 679-683. doi:10.1016/j.soard.2013.12.016


Author Rouskas, Konstantinos
Cauchi, Stephane
Raverdy, Violeta
Yengo, Loic
Froguel, Philippe
Pattou, Francois
Title Weight loss independent association of TCF7 L2 gene polymorphism with fasting blood glucose after Roux-en-Y gastric bypass in type 2 diabetic patients
Formatted title
Weight loss independent association of TCF7 L2 gene polymorphism with fasting blood glucose after Roux-en-Y gastric bypass in type 2 diabetic patients
Journal name Surgery for Obesity and Related Diseases   Check publisher's open access policy
ISSN 1878-7533
1550-7289
Publication date 2014-07-01
Sub-type Article (original research)
DOI 10.1016/j.soard.2013.12.016
Open Access Status Not yet assessed
Volume 10
Issue 4
Start page 679
End page 683
Total pages 5
Place of publication Philadelphia, PA, United States
Publisher Elsevier
Language eng
Formatted abstract
Background: Roux-en-Y gastric bypass (RYGB) surgery improves glucose control in most but not all patients with type 2 diabetes mellitus (T2 DM). Transcription factor 7-like 2 (TCF7 L2) gene variation (rs790314O, C: wild-type allele, T: risk-allele) is the strongest contributor to T2 DM risk. Until now, there are no studies investigating gene interactions with changes of glycemia in obese patients with T2 DM after RYGB. The objective of this study was to assess the effect of TCF7 L2 genotype on RYGB-induced changes in glucose homeostasis in 99 obese patients with T2 DM at 1- year follow-up.

Methods: Body mass index (BMI) and fasting blood glucose (FBG) were measured before and 1, 3, 6, and 12 months after RYGB. Genotyping was performed with TaqMan technology. The effect of the interaction between TCF7 L2 genotype and postoperative time on BMI and FBG changes was analyzed with a linear mixed model.

Results: Preoperatively, there was no difference in BMI, FBG, and other diabetes associated traits between homozygous (CC) (n = 49) and heterozygous (CT) or homozygous (TT) T risk-allele carriers (n 50). One year after RYGB, 48 out of 99 patients had glycosylated hemoglobin (HbA1 c) lower than 6.5% in absence of any antidiabetic medication. BMI decreased similarly in both groups (P = .769, genotype-time interaction), however, the decrease in FBG over time was lower in T risk-allele carriers (P = .0 16, genotype-time interaction). At 1 year, FBG was 6.42 2.98 mmol/ L in CT/TT versus 5.36 0.98 mmol/L in CC (P = .022, t test).

Conclusion: TCF7 L2 gene variation affected the decrease of FBG after RYGB in obese patients with T2 DM, independently of weight loss.
Keyword Bariatric surgery
TCF7 L2 gene variation
Type 2 Diabetes Mellitus
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Institute for Molecular Bioscience - Publications
 
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