Coffee and tea consumption, genotype-based CYP1A2 and NAT2 activity and colorectal cancer risk - results from the EPIC cohort study

Dik, Vincent K., Bueno-de-Mesquita, H. B(as), Van Oijen, Martijn G. H., Siersema, Peter D., Uiterwaal, Cuno S. P. M., Van Gils, Carla H., Van Duijnhoven, Fraenzel J. B., Cauchi, Stephane, Yengo, Loic, Froguel, Philippe, Overvad, Kim, Bech, Bodil H., Tjonneland, Anne, Olsen, Anja, Boutron-Ruault, Marie-Christine, Racine, Antoine, Fagherazzi, Guy, Kuehn, Tilman, Campa, Daniele, Boeing, Heiner, Aleksandrova, Krasimira, Trichopoulou, Antonia, Peppa, Eleni, Oikonomou, Eleni, Palli, Domenico, Grioni, Sara, Vineis, Paolo, Tumino, Rosaria, Panico, Salvatore, Peeters, Petra H. M., Weiderpass, Elisabete, Engeset, Dagrun, Braaten, Tonje, Dorronsoro, Miren, Chirlaque, Maria-Dolores, Sanchez, Maria-Jose, Barricarte, Aurelio, Zamora-Ros, Raul, Argueelles, Marcial, Jirstroem, Karin, Wallstroem, Peter, Nilsson, Lena M., Ljuslinder, Ingrid, Travis, Ruth C., Khaw, Kay-Tee, Wareham, Nick, Freisling, Heinz, Licaj, Idlir, Jenab, Mazda, Gunter, Marc J., Murphy, Neil, Romaguera-Bosch, Dora and Riboli, Elio (2014) Coffee and tea consumption, genotype-based CYP1A2 and NAT2 activity and colorectal cancer risk - results from the EPIC cohort study. International Journal of Cancer, 135 2: 401-412. doi:10.1002/ijc.28655


Author Dik, Vincent K.
Bueno-de-Mesquita, H. B(as)
Van Oijen, Martijn G. H.
Siersema, Peter D.
Uiterwaal, Cuno S. P. M.
Van Gils, Carla H.
Van Duijnhoven, Fraenzel J. B.
Cauchi, Stephane
Yengo, Loic
Froguel, Philippe
Overvad, Kim
Bech, Bodil H.
Tjonneland, Anne
Olsen, Anja
Boutron-Ruault, Marie-Christine
Racine, Antoine
Fagherazzi, Guy
Kuehn, Tilman
Campa, Daniele
Boeing, Heiner
Aleksandrova, Krasimira
Trichopoulou, Antonia
Peppa, Eleni
Oikonomou, Eleni
Palli, Domenico
Grioni, Sara
Vineis, Paolo
Tumino, Rosaria
Panico, Salvatore
Peeters, Petra H. M.
Weiderpass, Elisabete
Engeset, Dagrun
Braaten, Tonje
Dorronsoro, Miren
Chirlaque, Maria-Dolores
Sanchez, Maria-Jose
Barricarte, Aurelio
Zamora-Ros, Raul
Argueelles, Marcial
Jirstroem, Karin
Wallstroem, Peter
Nilsson, Lena M.
Ljuslinder, Ingrid
Travis, Ruth C.
Khaw, Kay-Tee
Wareham, Nick
Freisling, Heinz
Licaj, Idlir
Jenab, Mazda
Gunter, Marc J.
Murphy, Neil
Romaguera-Bosch, Dora
Riboli, Elio
Title Coffee and tea consumption, genotype-based CYP1A2 and NAT2 activity and colorectal cancer risk - results from the EPIC cohort study
Formatted title
Coffee and tea consumption, genotype-based CYP1A2 and NAT2 activity and colorectal cancer risk - results from the EPIC cohort study
Journal name International Journal of Cancer   Check publisher's open access policy
ISSN 1097-0215
0020-7136
Publication date 2014-07-15
Year available 2013
Sub-type Article (original research)
DOI 10.1002/ijc.28655
Open Access Status Not yet assessed
Volume 135
Issue 2
Start page 401
End page 412
Total pages 12
Place of publication Hoboken, NJ, United States
Publisher John Wiley & Sons
Language eng
Formatted abstract
Coffee and tea contain numerous antimutagenic and antioxidant components and high levels of caffeine that may protect against colorectal cancer (CRC). We investigated the association between coffee and tea consumption and CRC risk and studied potential effect modification by CYP1A2 and NAT2 genotypes, enzymes involved in the metabolization of caffeine. Data from 477,071 participants (70.2% female) of the European Investigation into Cancer and Nutrition (EPIC) cohort study were analyzed. At baseline (1992-2000) habitual (total, caffeinated and decaffeinated) coffee and tea consumption was assessed with dietary questionnaires. Cox proportional hazards models were used to estimate adjusted hazard ratio's (HR) and 95% confidence intervals (95% CI). Potential effect modification by genotype-based CYP1A2 and NAT2 activity was studied in a nested case-control set of 1,252 cases and 2,175 controls. After a median follow-up of 11.6 years, 4,234 participants developed CRC (mean age 64.7-±-8.3 years). Total coffee consumption (high vs. non/low) was not associated with CRC risk (HR 1.06, 95% CI 0.95-1.18) or subsite cancers, and no significant associations were found for caffeinated (HR 1.10, 95% CI 0.97-1.26) and decaffeinated coffee (HR 0.96, 95% CI 0.84-1.11) and tea (HR 0.97, 95% CI 0.86-1.09). High coffee and tea consuming subjects with slow CYP1A2 or NAT2 activity had a similar CRC risk compared to non/low coffee and tea consuming subjects with a fast CYP1A2 or NAT2 activity, which suggests that caffeine metabolism does not affect the link between coffee and tea consumption and CRC risk. This study shows that coffee and tea consumption is not likely to be associated with overall CRC.

What's new? Coffee and tea contain numerous compounds that may protect against colorectal cancer (CRC). In this study of more than 475,000 participants over more than a decade, the authors investigated whether coffee or tea consumption is associated with an altered risk of developing CRC. They also asked whether genetic variations in two enzymes involved in caffeine metabolism (CYP1A2 and NAT2) might affect this risk. They conclude that neither consumption patterns, nor genetic differences in caffeine metabolism, appear to have a significant impact on CRC risk.
Keyword Coffee
Colorectal cancer
CYP1A2
NAT2
Tea
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Institute for Molecular Bioscience - Publications
 
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