Cerebral cryptococcoma mimicking glioblastoma

Ulett, Kimberly B., Cockburn, James W. J., Jeffree, Rosalind and Woods, Marion L. (2017) Cerebral cryptococcoma mimicking glioblastoma. BMJ Case Reports, 2017 . doi:10.1136/bcr-2016-218824


Author Ulett, Kimberly B.
Cockburn, James W. J.
Jeffree, Rosalind
Woods, Marion L.
Title Cerebral cryptococcoma mimicking glioblastoma
Journal name BMJ Case Reports   Check publisher's open access policy
ISSN 1757-790X
Publication date 2017-02-01
Year available 2017
Sub-type Article (original research)
DOI 10.1136/bcr-2016-218824
Open Access Status Not yet assessed
Volume 2017
Total pages 1
Place of publication London, United Kingdom
Publisher BMJ Group
Collection year 2018
Language eng
Formatted abstract
Cryptococcus neoformans and C. gattii cause invasive fungal disease, with meningitis being the most common manifestation of central nervous system (CNS) disease. Encapsulated cryptococcomas occur rarely, predominantly in immunocompetent hosts, usually related to C. gattii. Our patient was an immunocompetent man who presented with headache and a large cystic CNS lesion thought to be glioblastoma. Biopsy of a concomitant lung lesion confirmed cryptococcoma and empiric antifungal therapy was started for presumed CNS cryptococcoma. Antifungal therapy failed to shrink the CNS lesion, and surgical excision confirmed C. gattii CNS cryptococcoma. Following surgery he had complete resolution of symptoms. This case highlights that cryptococcoma cannot be distinguished from tumour on clinical or imaging findings. A combined medical and surgical approach is optimal for the management of large or surgically accessible cryptococcomas, as antifungal therapy alone is unlikely to penetrate large lesions sufficiently to lead to a cure.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
School of Medicine Publications
 
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Created: Tue, 28 Feb 2017, 01:00:09 EST by Web Cron on behalf of Royal Brisbane Clinical School