Activation of NK cell cytotoxicity

Smyth, Mark J., Cretney, Erika, Kelly, Janice M., Westwood, Jennifer A., Street, Shayna E. A., Yagita, Hideo, Takeda, Kazuyoshi, van Dommelen, Serani L. H., Degli-Espostic, Mariapia A. and Hayakawa, Yoshihiro (2005) Activation of NK cell cytotoxicity. Molecular Immunology, 42 4: 501-510. doi:10.1016/j.molimm.2004.07.034

Author Smyth, Mark J.
Cretney, Erika
Kelly, Janice M.
Westwood, Jennifer A.
Street, Shayna E. A.
Yagita, Hideo
Takeda, Kazuyoshi
van Dommelen, Serani L. H.
Degli-Espostic, Mariapia A.
Hayakawa, Yoshihiro
Title Activation of NK cell cytotoxicity
Journal name Molecular Immunology   Check publisher's open access policy
ISSN 0161-5890
Publication date 2005
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.molimm.2004.07.034
Volume 42
Issue 4
Start page 501
End page 510
Total pages 10
Place of publication United Kingdom
Publisher Pergamon
Language eng
Abstract Natural killer (NK) cells are innate effector lymphocytes necessary for defence against stressed, microbe-infected, or malignant cells. NK cells kill target cells by either of two major mechanisms that require direct contact between NK cells and target cells. In the first pathway, cytoplasmic granule toxins, predominantly a membrane-disrupting protein known as perforin, and a family of structurally related serine C, proteases (granzymes) with various substrate specificities, are secreted by exocytosis and together induce apoptosis of the target cell. The granule-exocytosis pathway potently activates cell-death mechanisms that operate through the activation of apoptotic cysteine proteases (caspases), but can also cause cell death in the absence of activated caspases. The second pathway involves the engagement of death receptors (e.g. Fas/CD95) on target cells by their cognate ligands (e.g. FasL on NK cells, resulting in classical caspase-dependent apoptosis. The comparative role of these pathways in the pathophysiology of many diseases is being dissected by analyses of gene-targeted mice that lack these molecules, and humans who have genetic mutations affecting these pathways. We are also now learning that the effector function of NK cells is controlled by interactions involving specific NK cell receptors and their cognate ligands, either on target cells, or other cells of the immune system. This review will discuss the functional importance of NK cell cytotoxicity and the receptor/ligand interactions that control these processes. (C) 2004 Elsevier Ltd. All rights reserved.
Keyword Biochemistry & Molecular Biology
Apoptosis-inducing Ligand
Granule Serine Proteases
Dipeptidyl Peptidase-i
Nkg2d Receptor
Mediated Apoptosis
Cutting Edge
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Excellence in Research Australia (ERA) - Collection
UQ Diamantina Institute Publications
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Citation counts: TR Web of Science Citation Count  Cited 212 times in Thomson Reuters Web of Science Article | Citations
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Created: Mon, 13 Aug 2007, 15:00:47 EST