Review: The role of multiple placental glucocorticoid receptor isoforms in adapting to the maternal environment and regulating fetal growth

Clifton, V. L., Cuffe, J., Moritz, K. M., Cole, T. J., Fuller, P. J., Lu, N. Z., Kumar, S., Chong, S. and Saif, Z. (2016) Review: The role of multiple placental glucocorticoid receptor isoforms in adapting to the maternal environment and regulating fetal growth. Placenta, . doi:10.1016/j.placenta.2016.12.017


Author Clifton, V. L.
Cuffe, J.
Moritz, K. M.
Cole, T. J.
Fuller, P. J.
Lu, N. Z.
Kumar, S.
Chong, S.
Saif, Z.
Title Review: The role of multiple placental glucocorticoid receptor isoforms in adapting to the maternal environment and regulating fetal growth
Journal name Placenta   Check publisher's open access policy
ISSN 1532-3102
0143-4004
Publication date 2016-12-19
Sub-type Article (original research)
DOI 10.1016/j.placenta.2016.12.017
Open Access Status Not yet assessed
Total pages 6
Place of publication London, United Kingdom
Publisher Elsevier
Collection year 2017
Language eng
Abstract The physiological mechanisms that confer different outcomes in morbidity and mortality of the fetus exposed to stressful environments may be driven by significant differences in the expression and function of the placental glucocorticoid receptor (GR). The recent discovery that the placenta contains at least 8 different isoforms of the GR raises questions about the regulation and physiological relevance of the many GR variants expressed in the placenta. The current data also highlights that individual differences in glucocorticoid sensitivity, variations in the effect of different complications of pregnancy on birth outcomes and sex differences in the response to stress, may all be dependent on a specific GR isoform expression profile. This review will investigate the current state of knowledge of GR isoforms in the placenta and discuss the potential role of these multiple isoforms in regulating glucocorticoid sensitivity.
Keyword Fetus
Glucocorticoid receptor isoforms
Placenta
Sex
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

 
Versions
Version Filter Type
Citation counts: Scopus Citation Count Cited 0 times in Scopus Article
Google Scholar Search Google Scholar
Created: Tue, 31 Jan 2017, 00:21:27 EST by System User on behalf of Learning and Research Services (UQ Library)