Tyrosol exerts a protective effect against dopaminergic cell death in in vitro model of Parkinson's disease

Dewapriya, Pradeep, Himaya, S. W. A., Li, Yong-Xin and Kim, Se-Kwon (2013) Tyrosol exerts a protective effect against dopaminergic cell death in in vitro model of Parkinson's disease. Food Chemistry, 141 2: 1147-1157. doi:10.1016/j.foodchem.2013.04.004


Author Dewapriya, Pradeep
Himaya, S. W. A.
Li, Yong-Xin
Kim, Se-Kwon
Title Tyrosol exerts a protective effect against dopaminergic cell death in in vitro model of Parkinson's disease
Journal name Food Chemistry   Check publisher's open access policy
ISSN 0308-8146
1873-7072
Publication date 2013-11-15
Sub-type Article (original research)
DOI 10.1016/j.foodchem.2013.04.004
Open Access Status Not yet assessed
Volume 141
Issue 2
Start page 1147
End page 1157
Total pages 11
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Language eng
Formatted abstract
Experimental evidence suggests that tyrosol [2-(4-hydroxyphenyl)ethanol] exhibits potent protective activities against several pathogeneses. In this study, we evaluated the protective effect of tyrosol against 1-methyl-4-phenylpyridinium (MPP+)-induced CATH.a neuron cell death. Tyrosol dose-dependently protected CATH.a cells from MPP+-induced cell death and the protection was more apparent after prolong incubation (48 h). The data showed that tyrosol treatment suppressed the reduction of phospho-tyrosine hydroxylase level in CATH.a cells. Further, the compound repressed MPP+-induced depletion of mitochondrial membrane potential (Δψm) and thereby maintained intracellular ATP production in the cell. The cellular signalling pathway studies revealed that tyrosol protected CATH.a cells from MPP+-induced apoptotic signalling, most likely via activation of PI3K/Akt signalling pathway along with up-regulation of anti-oxidative enzymes (SOD-1 and SOD-2) and DJ-1 protein in the cell. Collectively, present study demonstrates that tyrosol significantly protects dopaminergic neurons from MPP+-induced degradation, and reveals potential neuroprotective mechanism of tyrosol.
Keyword Tyrosol
Antioxidant
Neuroprotection
Parkinson’s disease
Oxidative stress
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Institute for Molecular Bioscience - Publications
 
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Created: Mon, 23 Jan 2017, 11:01:55 EST by Himaya Siddhihalu Wickrama Hewage on behalf of Institute for Molecular Bioscience