The effect of tidal volume and peep on CO2 and oxygenation during resuscitation of very premature lambs

Morley, C. J., Probyn, M., Hooper, S., Dargaville, P., McCallion, N., Nicholas, T. and Harding, R. (2004). The effect of tidal volume and peep on CO2 and oxygenation during resuscitation of very premature lambs. In: Abstracts of the 45 th Annual Meeting of the European Society for Paediatric Research. 45 th Annual Meeting of the European Society for Paediatric Research, Stockholm, Sweden, (496-496). September 19-22, 2004. doi:10.1203/00006450-200409000-00213


Author Morley, C. J.
Probyn, M.
Hooper, S.
Dargaville, P.
McCallion, N.
Nicholas, T.
Harding, R.
Title of paper The effect of tidal volume and peep on CO2 and oxygenation during resuscitation of very premature lambs
Conference name 45 th Annual Meeting of the European Society for Paediatric Research
Conference location Stockholm, Sweden
Conference dates September 19-22, 2004
Proceedings title Abstracts of the 45 th Annual Meeting of the European Society for Paediatric Research   Check publisher's open access policy
Journal name Pediatric Research   Check publisher's open access policy
Place of Publication Baltimore, MD
Publisher Lippincott, William & Wilkins
Publication Year 2004
Sub-type Published abstract
DOI 10.1203/00006450-200409000-00213
ISSN 0031-3998
Volume 56
Issue 3
Start page 496
End page 496
Total pages 1
Language eng
Abstract/Summary Background: Over-ventilation causing low arterial carbon dioxide levels (PaCO2) has been associated with the development of neonatal chronic lung disease and adverse outcomes. This may occur very soon after birth. Aim: To investigate the effect on PaCO2 and oxygenation of very premature lambs resuscitated with different tidal volumes and PEEP. Methods: Anaesthetised lambs delivered at 126 days gestation were randomised to 15 min resuscitation with 3 regimes: (1) Laerdal resuscitation bag (B) with 100% oxygen and no PEEP, (2) fixed tidal volume (VT) of 5 mL/kg, or (3) VT of 10 mL/kg, both delivered with a Babylog 8000 ventilator in volume guarantee mode with 8 cm H2O PEEP and variable FiO2. Frequent blood gases were measured and VT, mean airway pressure (Paw), minute volume (MV), ventilation rate (VR), respiratory system compliance (Crs) and alveolar/arterial oxygen difference (AaDO2) were recorded. Results: Twenty lambs were studied. B (1) was associated with more variable VT and peak inspiratory pressures (PIP) compared to fixed tidal volumes (2 and 3). The lambs ventilated with 10 mL/kg were over-ventilated, those ventilated with 5 mL/kg were slightly under-ventilated. Those ventilated with the Laerdal bag had a mean VT of 7.5 mL/kg and were normocarbic. The different tidal volumes had little effect on oxygenation. PEEP improved oxygenation. The table shows the values at 15 minutes expressed as mean and SEM. TABLE. No caption av... TABLE. No caption av... Image Tools Conclusion: Very premature lambs can be effectively resuscitated from birth using volume guarantee ventilation. Within minutes of birth different tidal volumes had a large effect on PaCO2 and no effect on oxygenation. Studies are needed to determine the appropriate tidal volume for resuscitating very premature infants to maintain acceptable levels of PaCO2. © International Pediatrics Research Foundation, Inc. 2004. All Rights Reserved.
Subjects 11 Medical and Health Sciences
Keyword Pediatrics
Q-Index Code EX
Q-Index Status Provisional Code
Institutional Status Unknown

 
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Created: Tue, 14 Aug 2007, 00:34:08 EST