A neurophysiological study of semantic processing in Parkinson’s disease

Angwin, Anthony J., Dissanayaka, Nadeeka N. W., Moorcroft, Alison, McMahon, Katie L., Silburn, Peter A. and Copland, David A. (2016) A neurophysiological study of semantic processing in Parkinson’s disease. Journal of the International Neuropsychological Society, 1-12. doi:10.1017/S1355617716000953


 
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Author Angwin, Anthony J.
Dissanayaka, Nadeeka N. W.
Moorcroft, Alison
McMahon, Katie L.
Silburn, Peter A.
Copland, David A.
Title A neurophysiological study of semantic processing in Parkinson’s disease
Journal name Journal of the International Neuropsychological Society   Check publisher's open access policy
ISSN 1469-7661
1355-6177
Publication date 2016-12-05
Sub-type Article (original research)
DOI 10.1017/S1355617716000953
Open Access Status Not yet assessed
Start page 1
End page 12
Total pages 12
Place of publication Cambridge, United Kingdom
Publisher Cambridge University Press
Collection year 2017
Language eng
Formatted abstract
Objectives: Cognitive-linguistic impairments in Parkinson’s disease (PD) have been well documented; however, few studies have explored the neurophysiological underpinnings of semantic deficits in PD. This study investigated semantic function in PD using event-related potentials.

Methods: Eighteen people with PD and 18 healthy controls performed a semantic judgement task on written word pairs that were either congruent or incongruent.

Results: The mean amplitude of the N400 for new incongruent word pairs was similar for both groups, however the onset latency was delayed in the PD group. Further analysis of the data revealed that both groups demonstrated attenuation of the N400 for repeated incongruent trials, as well as attenuation of the P600 component for repeated congruent trials.

Conclusions: The presence of N400 congruity and N400 repetition effects in the PD group suggests that semantic processing is generally intact, but with a slower time course as evidenced by the delayed N400. Additional research will be required to determine whether N400 and P600 repetition effects are sensitive to further cognitive decline in PD.
Keyword Event-related potentials
Memory
N400
P600
Parkinson’s disease
Semantics
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

 
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