Aortic pressure during exercise is significantly elevated with age and hypercholesterolemia

Sharman, JE, McEniery, CM, Coombes, JS, Wilkinson, IB and Cockcroft, JR (2004). Aortic pressure during exercise is significantly elevated with age and hypercholesterolemia. In: Journal of hypertension. 14th European Meeting on Hypertension, Paris, France, (S332-S333). 13-17 Jun 2004.

Author Sharman, JE
McEniery, CM
Coombes, JS
Wilkinson, IB
Cockcroft, JR
Title of paper Aortic pressure during exercise is significantly elevated with age and hypercholesterolemia
Conference name 14th European Meeting on Hypertension
Conference location Paris, France
Conference dates 13-17 Jun 2004
Proceedings title Journal of hypertension   Check publisher's open access policy
Journal name Journal of Hypertension   Check publisher's open access policy
Place of Publication Philadelphia, PA, U.S.A.
Publisher Lippincott Williams & Wilkins
Publication Year 2004
Sub-type Published abstract
ISSN 0952-1178
Volume 22
Issue Supplement 2
Start page S332
End page S333
Total pages 2
Language eng
Formatted Abstract/Summary Objectives:
Due to amplification of pulse pressure, central (aortic) blood pressure may differ significantly from recordings at peripheral (e.g. brachial artery) sites. Although, the brachial blood pressure response to exercise and resting central blood pressures are more powerful predictors of cardiovascular outcome compared to resting peripheral measures alone, the effect of exercise on central blood pressure in people with risk factors for cardiovascular disease is unknown. This study aimed to assess the central and peripheral hemodynamic response to exercise with increasing age and hypercholesterolemia.

Design and Methods:

Twenty healthy young subjects (aged 29 ± 5 years; mean ± SD), 20 healthy older (aged 57 ± 5 years) and 10 matched hypercholesterolemic (aged 59 ± 7 years) men exercised at 60% of their predicted maximal heart rate on a bicycle ergometer. Central blood pressure and augmentation index (Alx), a marker of systemic arterial stiffness, were obtained non-invasively using pulse wave analysis. Amplification was calculated as the ratio of peripheral to central pulse pressure.

Resting hemodynamic measures were not different between the hypercholesterolemics and controls. During exercise there was no difference in brachial SBP (P=0.7), but hypercholesterolemics had significantly higher mean arterial pressure, brachial diastolic blood pressure (DBP), central systolic blood pressure (SBP), and Alx (P<0.05 for all). Young subjects had significantly lower Alx and central SBP during exercise (P<0.001) compared to older subjects. For the whole population, total cholesterol and amplification during exercise were negatively correlated (r = -0.60; P 0.001).


With increasing age, wave reflection is augmented during exercise, resulting in elevated central pressure. These effects are exacerbated by hypercholesterolemia and would contribute to cardiovascular risk by mechanisms associated with central hypertension.
Subjects EX
1117 Public Health and Health Services
Keyword Peripheral Vascular Disease
Q-Index Code EX
Additional Notes [Abstract: Wednesday, June 16, 2004: POSTER SESSIONS: Poster Session 50: Blood Vessels]

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Created: Mon, 13 Aug 2007, 14:31:18 EST