Mentalizing in schizophrenia: A multivariate functional MRI study

Martin, Andrew K., Dzafic, Ilvana, Robinson, Gail A., Reutens, David and Mowry, Bryan (2016) Mentalizing in schizophrenia: A multivariate functional MRI study. Neuropsychologia, 93 158-166. doi:10.1016/j.neuropsychologia.2016.10.013


Author Martin, Andrew K.
Dzafic, Ilvana
Robinson, Gail A.
Reutens, David
Mowry, Bryan
Title Mentalizing in schizophrenia: A multivariate functional MRI study
Journal name Neuropsychologia   Check publisher's open access policy
ISSN 0028-3932
1873-3514
Publication date 2016-12-01
Year available 2016
Sub-type Article (original research)
DOI 10.1016/j.neuropsychologia.2016.10.013
Open Access Status Not yet assessed
Volume 93
Start page 158
End page 166
Total pages 9
Place of publication Kidlington, Oxford, United Kingdom
Publisher Pergamon Press
Collection year 2017
Language eng
Formatted abstract
Schizophrenia is associated with mentalizing deficits that impact on social functioning and quality of life. Recently, schizophrenia has been conceptualized as a disorder of neural dysconnectivity and network level analyses offers a means of understanding the underlying deficits leading to mentalizing difficulty. Using an established mentalizing task (The Triangles Task), functional magnetic resonance images (fMRI) were acquired from 19 patients with schizophrenia and 17 age- and sex-matched healthy controls (HCs). Participants were required to watch short animations of two triangles interacting with each other with the interactions either random (no interaction), physical (patterned movement), or mental (intentional movement). Task-based Partial Least Squares (PLS) was used to analyze activation differences and commonalities between the three conditions and the two groups. Seed-based PLS was used to assess functional connectivity with peaks identified in the task-based PLS. Behavioural PLS was then performed using the accuracy from the mental conditions. Patients with schizophrenia performed worse on the mentalizing condition compared to HCs. Task-based PLS revealed one significant latent variable (LV) that explained 42.9% of the variance in the task, with theLV separating the mental condition from the physical and random conditions in patients with schizophrenia, but only the mental from physical in healthy controls. The mental animations were associated with increased modulation of the inferior frontal gyri bilaterally, left superior temporal gyrus, right postcentral gyrus, and left caudate nucleus. The physical/random animations were associated with increased modulation of the right medial frontal gyrus and left superior frontal gyrus. Seed-based PLS identified increased functional connectivity with the left inferior frontal gyrus (liFG) and caudate nucleus in patients with schizophrenia, during the mental and physical interactions, with functional connectivity with the liFG associated with increased performance on the mental animations. The results suggest that mentalizing deficits in schizophrenia may arise due to inefficient social brain networks.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

 
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