The impact of cardiorespiratory fitness levels on the risk of developing atherogenic dyslipidemia

Breneman, Charity B., Polinski, Kristen, Sarzynski, Mark A., Lavie, Carl J., Kokkinos, Peter F., Ahmed, Ali and Sui, Xuemei (2016) The impact of cardiorespiratory fitness levels on the risk of developing atherogenic dyslipidemia. American Journal of Medicine, 129 10: 1060-1066. doi:10.1016/j.amjmed.2016.05.017

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Author Breneman, Charity B.
Polinski, Kristen
Sarzynski, Mark A.
Lavie, Carl J.
Kokkinos, Peter F.
Ahmed, Ali
Sui, Xuemei
Title The impact of cardiorespiratory fitness levels on the risk of developing atherogenic dyslipidemia
Journal name American Journal of Medicine   Check publisher's open access policy
ISSN 1555-7162
0002-9343
Publication date 2016-10-01
Sub-type Article (original research)
DOI 10.1016/j.amjmed.2016.05.017
Open Access Status File (Author Post-print)
Volume 129
Issue 10
Start page 1060
End page 1066
Total pages 7
Place of publication New York, NY 10010 United States
Publisher Elsevier
Collection year 2017
Language eng
Formatted abstract
Background: Low cardiorespiratory fitness has been established as a risk factor for cardiovascular-related morbidity. However, research about the impact of fitness on lipid abnormalities, including atherogenic dyslipidemia, has produced mixed results. The purpose of this investigation is to examine the influence of baseline fitness and changes in fitness on the development of atherogenic dyslipidemia.

Methods: All participants completed at least 3 comprehensive medical examinations performed by a physician that included a maximal treadmill test between 1976 and 2006 at the Cooper Clinic in Dallas, Texas. Atherogenic dyslipidemia was defined as a triad of lipid abnormalities: low high-density-lipoprotein cholesterol ([HDL-C] <40 mg/dL), high triglycerides ([TGs] ≥200 mg/dL), and high low-density-lipoprotein cholesterol ([LDL-C] ≥160 mg/dL).

Results: A total of 193 participants developed atherogenic dyslipidemia during an average of 8.85 years of follow-up. High baseline fitness was protective against the development of atherogenic dyslipidemia in comparison with those with low fitness (odds ratio [OR] 0.57; 95% confidence interval [CI], 0.37-0.89); however, this relationship became nonsignificant after controlling for baseline HDL-C, LDL-C, and TG levels. Participants who maintained fitness over time had lower odds of developing atherogenic dyslipidemia than those with a reduction in fitness (OR 0.56; 95% CI, 0.34-0.91) after adjusting for baseline confounders and changes in known risk factors.

Conclusions: High fitness at baseline and maintenance of fitness over time are protective against the development of atherogenic dyslipidemia.
Keyword Cholesterol
Dyslipidemia
Epidemiology
Exercise capacity
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
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