Cytokine expanded myeloid precursors function as regulatory antigen presenting cells and induce tolerance through IL-10 producing regulatory T cells

MacDonald, K. P. A., Rowe, V., Thomas, R., Ferrera, J. L. M. and Hill, G. R. (2004). Cytokine expanded myeloid precursors function as regulatory antigen presenting cells and induce tolerance through IL-10 producing regulatory T cells. In: Immunology and Cell Biology. 22nd Annual Scientific Meeting of the Transplantation Society of Australia and New Zealand, Canberra, Australia, (A15-A15). 31st March - 2nd April, 2004. doi:10.1111/j.1440-1711.2004.1259_2.x


Author MacDonald, K. P. A.
Rowe, V.
Thomas, R.
Ferrera, J. L. M.
Hill, G. R.
Title of paper Cytokine expanded myeloid precursors function as regulatory antigen presenting cells and induce tolerance through IL-10 producing regulatory T cells
Conference name 22nd Annual Scientific Meeting of the Transplantation Society of Australia and New Zealand
Conference location Canberra, Australia
Conference dates 31st March - 2nd April, 2004
Proceedings title Immunology and Cell Biology   Check publisher's open access policy
Journal name Immunology and Cell Biology   Check publisher's open access policy
Place of Publication Basingstoke, U.K.
Publisher Nature Publishing Group
Publication Year 2004
DOI 10.1111/j.1440-1711.2004.1259_2.x
ISSN 0818-9641
1440-1711
Volume 82
Issue 2
Start page A15
End page A15
Total pages 2
Language eng
Abstract/Summary The initiation of graft vs. host disease (GVHD) after stem cell transplantation is dependent on direct antigen presentation by host antigen presenting cells (APC) while the effect of indirect antigen presentation by donor APC is unknown. We have studied the role of indirect antigen presentation in allogenic responses by adding populations of cytokine-expanded donor APC to haematopoietic grafts that would otherwise induce lethal GVHD. Progenipoietin-1 (a synthetic G-CSF/Flt-3 L molecule) and G-CSF expanded myeloid DC, plasmacytoid DC and a novel granulocyte-monocyte precursor population (GM) that differentiate into class IIpos, CD80/CD86pos, CD40neg APC during GVHD. Whereas addition of plasmacytoid and myeloid donor DC augmented GVHD, GM cells induced transplant tolerance via MHC class II restricted generation of IL-10-secreting regulatory T cells. Thus a population of cytokine expanded granulocyte-monocyte precursors function as regulatory antigen presenting cells, suggesting that G-CSF derivatives may have application in disorders characterised by a loss of self-tolerance.
Subjects 1107 Immunology
Keyword Cell Biology
Immunology
Q-Index Code EX
Q-Index Status Provisional Code
Institutional Status Unknown

 
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Created: Tue, 14 Aug 2007, 00:13:39 EST