Neurofilaments as biomarkers for amyotrophic lateral sclerosis: a systematic review and meta-analysis

Xu, Zhouwei, Henderson, Robert David, David, Michael and McCombe, Pamela Ann (2016) Neurofilaments as biomarkers for amyotrophic lateral sclerosis: a systematic review and meta-analysis. PLoS ONE, 11 10: . doi:10.1371/journal.pone.0164625


Author Xu, Zhouwei
Henderson, Robert David
David, Michael
McCombe, Pamela Ann
Title Neurofilaments as biomarkers for amyotrophic lateral sclerosis: a systematic review and meta-analysis
Journal name PLoS ONE   Check publisher's open access policy
ISSN 1932-6203
Publication date 2016-10-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1371/journal.pone.0164625
Open Access Status DOI
Volume 11
Issue 10
Total pages 18
Place of publication San Francisco, CA, United States
Publisher Public Library of Science
Collection year 2017
Language eng
Formatted abstract
Background: To allow early diagnosis and monitoring of disease progression, there is a need for biomarkers in amyotrophic lateral sclerosis (ALS). Neurofilaments (NF) are emerging protein biomarkers in other neurological diseases, and are of possible use in ALS.

Objective: The aim of this study is to evaluate the utility of NF levels as blood or cerebrospinal fluid (CSF) biomarker in patients with ALS.

Methods: A systematic search of Pubmed, Embase and Scopus was performed. Methodological quality assessment was applied to refine the final search results. Meta-analysis of the data was performed.

Results: Level of NF heavy chain and light chains were significantly elevated in the CSF of ALS patients compared to healthy controls/controls without parenchymal central nervous system (CNS) involvement and ALS mimic disease patients. NF light chain level in CSF was higher in ALS patients than in neurological patients with CNS involvement (SMD = 1.352, P = 0.01). NF light chain concentration in blood was higher in ALS patients than healthy controls/controls without CNS involvement (SMD = 1.448, P<0.0001). NF heavy chain levels in CSF were negatively correlated disease duration and ALSFRS-R ((r = -0.447, P<0.0001; r = -0.486, P<0.0001). NF light chain levels in CSF were negatively correlated with disease duration (r = -0.273, P = 0.011).

Conclusion: NF heavy and light chain levels have potential use as a marker of neural degeneration in ALS, but are not specific for the disease, and are more likely to be used as measures of disease progression.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: UQ Centre for Clinical Research Publications
HERDC Pre-Audit
Admin Only - School of Medicine
School of Public Health Publications
School of Medicine Publications
Admin Only - UQCCR
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 1 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 2 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Tue, 01 Nov 2016, 10:48:05 EST by System User on behalf of Learning and Research Services (UQ Library)