Astroglial-mediated remodeling of the interhemispheric midline is required for the formation of the corpus callosum

Gobius, Ilan, Morcom, Laura, Sua´rez, Rodrigo, Bunt, Jens, Bukshpun, Polina, Reardon, William, Dobyns, William B., Rubenstein, John L.R., Barkovich, James, Sherr, Elliott H. and Richards, Linda J. (2016) Astroglial-mediated remodeling of the interhemispheric midline is required for the formation of the corpus callosum. Cell Reports, 17 3: 735-747. doi:10.1016/j.celrep.2016.09.033


Author Gobius, Ilan
Morcom, Laura
Sua´rez, Rodrigo
Bunt, Jens
Bukshpun, Polina
Reardon, William
Dobyns, William B.
Rubenstein, John L.R.
Barkovich, James
Sherr, Elliott H.
Richards, Linda J.
Title Astroglial-mediated remodeling of the interhemispheric midline is required for the formation of the corpus callosum
Journal name Cell Reports   Check publisher's open access policy
ISSN 2211-1247
Publication date 2016-10-11
Year available 2016
Sub-type Article (original research)
DOI 10.1016/j.celrep.2016.09.033
Open Access Status DOI
Volume 17
Issue 3
Start page 735
End page 747
Total pages 13
Place of publication New York, United States
Publisher Elsevier
Collection year 2017
Language eng
Formatted abstract
The corpus callosum is the major axon tract that connects and integrates neural activity between the two cerebral hemispheres. Although ∼1:4,000 children are born with developmental absence of the corpus callosum, the primary etiology of this condition remains unknown. Here, we demonstrate that midline crossing of callosal axons is dependent upon the prior remodeling and degradation of the intervening interhemispheric fissure. This remodeling event is initiated by astroglia on either side of the interhemispheric fissure, which intercalate with one another and degrade the intervening leptomeninges. Callosal axons then preferentially extend over these specialized astroglial cells to cross the midline. A key regulatory step in interhemispheric remodeling is the differentiation of these astroglia from radial glia, which is initiated by Fgf8 signaling to downstream Nfi transcription factors. Crucially, our findings from human neuroimaging studies reveal that developmental defects in interhemispheric remodeling are likely to be a primary etiology underlying human callosal agenesis.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Queensland Brain Institute Publications
School of Biomedical Sciences Publications
 
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